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Main Benefits
Stimulates Natural Collagen Production
GOURI revitalizes your skin by encouraging natural collagen regeneration, helping to restore firmness and elasticity for a youthful look.
Full-Face Rejuvenation
Unlike traditional fillers, GOURI spreads evenly across the skin, ensuring a smooth and natural-looking enhancement without lumpiness or uneven areas.
Long-Lasting Results
With biodegradable PCL technology, GOURI gradually improves skin texture and reduces wrinkles over time, with effects lasting up to a year.
Minimally Invasive & Safe
This injectable treatment requires minimal downtime and has been clinically tested for safety, making it a convenient option for facial rejuvenation.
Indications
GOURI is the 1st liquid type PCL (polycaprolactone) injectable. It rejuvenates our skin by promoting collagenesis on the entire face. Spreading naturally on the entire face, GOURI generates collagen synthesis which has decreased due to the skin-aging.
GOURI is formulated to target common signs of aging and skin concerns by stimulating natural collagen production:
Fine Lines & Wrinkles
Reduces the appearance of gravity wrinkles, nasolabial folds, and fine lines around the eyes.
Loss of Skin Firmness
Improves skin elasticity and lifts sagging skin for a firmer, more youthful look.
Poor Skin Texture & Roughness
Smooths uneven skin texture and enhances overall skin quality.
Volume Loss & Skin Depressions
Restores facial volume and improves areas affected by aging or collagen depletion.
This minimally invasive treatment delivers long-lasting results, making it an effective solution for those seeking natural-looking facial rejuvenation.
Ingredients
21% Fully Solubilized Polycaprolactone (PCL)
A biocompatible and biodegradable polymer that stimulates natural collagen production, helping to restore skin elasticity, smooth wrinkles, and improve overall skin texture over time.
Mechanism of Action
GOURI works by stimulating natural collagen production through its fully solubilized Polycaprolactone (PCL) formula, offering a gradual and natural facial rejuvenation without the need for microparticles or gel-like fillers. Unlike traditional dermal fillers, which simply add volume to specific areas, GOURI enhances the skin’s own regenerative abilities by promoting collagen synthesis throughout the face.
How It Works:
Injection & Even Distribution
- Unlike traditional fillers that stay in one place, GOURI spreads evenly across the skin after injection, reaching a wider treatment area.
- This even distribution ensures balanced collagen stimulation and prevents lumps or unnatural-looking results.
Collagen Stimulation Through CESABP Technology
- GOURI uses Collagen Enabled Solubilized Active and Biodegradable Polymer (CESABP) technology to trigger fibroblast activation—the key process for collagen production.
- Fibroblasts are the skin’s natural collagen-producing cells. When activated, they gradually restore skin elasticity, firmness, and volume from within.
Gradual Skin Renewal Over Time
- Over the course of six to twelve months, the newly generated collagen works to:
- Improve skin texture by smoothing fine lines and wrinkles.
- Restore lost volume by plumping areas affected by aging.
- Enhance skin hydration and elasticity, leading to a fresher, youthful look.
- Since GOURI stimulates the skin’s natural processes, the results appear gradual and natural, avoiding an overfilled or artificial look.
- Over the course of six to twelve months, the newly generated collagen works to:
Biodegradable & Long-Lasting Effects
- The PCL gradually breaks down via hydrolysis and is naturally absorbed by the body over time.
- Unlike hyaluronic acid fillers that dissolve quickly, GOURI’s effects last longer (up to a year) due to sustained collagen production.
Why It’s Different:
- Full-face rejuvenation – Unlike localized fillers, GOURI spreads evenly for a natural, youthful glow.
- Stimulates collagen at a deep level – Works with the body’s natural processes instead of just adding volume.
- Long-lasting effects – Results improve over time and last up to a year.
- Minimally invasive with no downtime – Provides gradual, noticeable improvements without drastic changes.
By activating fibroblasts and boosting collagen naturally, GOURI restores youthful skin quality from the inside out, ensuring a smooth, radiant, and lifted appearance.
Product Preparation
GOURI is supplied in a pre-filled, ready-to-use syringe containing 1 mL of fully solubilized Polycaprolactone (PCL) solution. No reconstitution or dilution is necessary before administration. The product is designed for direct injection by a qualified medical professional.
Inspect the Packaging:
- Ensure the sterile packaging is intact and the syringe is free from damage or tampering.
Verify Product Information:
- Confirm the expiration date is valid.
- Examine the solution for any discoloration or particulate matter; the solution should appear clear and consistent.
Prepare the Injection Site:
- Thoroughly cleanse and disinfect the patient’s skin at the intended injection sites using an appropriate antiseptic solution.
Attach the Appropriate Needle:
- Securely attach a sterile needle to the syringe.
- The specific needle size and type should be selected based on the injection technique and the practitioner’s professional judgment.
Remove Air Bubbles:
- Hold the syringe upright and gently tap to allow any air bubbles to rise.
- Carefully press the plunger to expel the air, ensuring only the solution remains in the syringe.
Additional Materials Needed:
- Sterile needles (size determined by the practitioner’s preference and injection technique).
- Antiseptic solution for skin preparation.
- Sterile gloves and standard aseptic supplies.
Note: GOURI should only be administered by licensed healthcare professionals trained in appropriate injection techniques. Adherence to standard aseptic procedures is essential to ensure patient safety and optimal results.
Treatment areas
GOURI is primarily designed for full-face rejuvenation, targeting various facial regions to enhance skin quality and address signs of aging.
Face Treatment Areas:
- Forehead & Glabella: Addresses horizontal forehead lines and frown lines between the eyebrows.
- Cheeks & Midface: Enhances volume and reduces sagging in the midface region.
- Nasolabial Folds: Softens the lines running from the sides of the nose to the corners of the mouth.
- Jawline & Chin: Improves definition and reduces the appearance of jowls.
- Periorbital Area: Targets fine lines and wrinkles around the eyes.
Dosage and technique
GOURI is administered through two primary injection techniques, ensuring even distribution and optimal collagen stimulation. The choice of technique depends on the practitioner’s expertise and the patient’s preference.
Each 1ml syringe of GOURI is designed for full-face rejuvenation. The standard treatment protocol includes three sessions spaced four weeks apart. Additional sessions may be required depending on the patient’s skin condition and response to treatment.
5-Point Injection Technique (10 Injection Points Total)
GOURI is injected at five bio-stimulatory points per side of the face. This method is more traditional but may lead to localized swelling or bruising due to multiple injection points.Cannula Injection Technique (4 Injection Points Total) – Preferred Method
The Cannula Technique is a less invasive and safer approach that minimizes swelling and bruising. It requires only two injection points per side of the face. Instead of a traditional needle, it uses a blunt-tipped cannula, which reduces trauma to surrounding tissue. A fine needle creates a small entry point, through which the cannula is inserted to distribute GOURI more evenly under the skin. To ensure patient comfort, a layer of numbing cream is applied beforehand.
Post-treatment
For the first 1-3 days, avoid touching or massaging the treated areas. Protect your skin by limiting sun exposure and applying broad-spectrum sunscreen. Stay away from heat sources like saunas, steam rooms, and hot baths, as they can increase swelling. Use a gentle skincare routine and avoid active ingredients like AHA, BHA, retinol, and vitamin C. Refrain from applying makeup on the treated areas to allow the skin to heal.
Avoid alcohol and blood-thinning medications to reduce bruising. Strenuous activities should be limited to prevent increased circulation from affecting the treated areas.
Stay hydrated to support skin recovery. Mild redness or swelling is normal and should subside within 24-48 hours. If you experience any unusual or persistent side effects, contact your provider.
Course of Treatments
How quickly will the result appear?
Before & Afters
What's Inside
1 pre-filled syringe (1ml) of fully solubilized Polycaprolactone (PCL)
FAQ
GOURI is the first fully liquid PCL (polycaprolactone) injectable that rejuvenates the skin by promoting collagen production across the entire face. It naturally spreads, enhancing collagen synthesis that diminishes with aging.
Results vary depending on individual conditions. Generally, initial visual improvements can be observed within 1–2 weeks post-treatment.
The duration of GOURI’s effects depends on the individual. Typically, PCL degrades in the body over 6–12 months, during which time the benefits of the treatment are maintained.
Currently, GOURI is recommended for facial use only. Clinical studies are ongoing to evaluate its efficacy and safety for other areas, such as the hands and neck.
Unlike existing products that mix polymer powders with liquids, GOURI is a fully liquid PCL injectable. This unique formulation allows it to spread evenly across the entire face, reducing the risk of complications and providing a more natural rejuvenation.
GOURI consists of 21% PCL (polycaprolactone).
Yes, DEXLEVO has successfully completed Phase-1 and Phase-2 clinical trials involving over 200 participants, demonstrating the safety and efficacy of GOURI.
GOURI is a PCL-based dermal injectable with a high molecular weight, making it resistant to dissolution post-injection. However, it does not cause immediate volumizing changes, so dissolution is typically unnecessary.
It is recommended to wait one month before or after other treatments when considering GOURI. While GOURI is compatible with non-crosslinked skin boosters or Botox, it should not be mixed with other products. For HA fillers and other cross-linked materials, a one-month interval is advisable.
GOURI has received CE approval, and all manufacturing facilities are ISO 13485 certified. KFDA approval is currently in progress and expected next year.
CESABP stands for Collagen Enabled Solubilized Active and Biodegradable Polymer Technology. This patented technology by DEXLEVO enables the regeneration of natural skin collagen without the use of microparticles, leading to effective skin rejuvenation.
Yes, Gouri is available through our wholesale program. As the first fully solubilized PCL injectable, Gouri spreads evenly across the face for natural full-face rejuvenation with results lasting up to one year. Wholesale purchasing enables you to maintain adequate inventory while managing costs effectively. To access wholesale rates, complete our Wholesale Application to get started.
How to store
Store GOURI at a controlled room temperature (5–25°C) in a dry place, away from direct sunlight and heat sources. Do not freeze, as extreme temperatures may affect the stability of the product.
The product must remain in its sterile, sealed packaging until ready for use. Once opened, it should be used immediately and not stored for future applications.
GOURI is a professional-grade injectable that must only be administered by licensed medical professionals trained in aesthetic procedures. Improper handling, storage, or use may result in compromised product quality and potential adverse effects. We are not liable for misuse or unauthorized administration.
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I truly love Gouri. I do the inniblanc technique and it really helps lift my face!
First time user. Can’t wait‼️
I’ve done 4 treatments 4 weeks apart and the results are stunning.
Product Benefits Collagen boost
Age 44
Great for improved collagen production. Takes time but worth the wait!
Product Benefits Improving lines and wrinkles
Age 44
Following the correct protocol this is an excellent product to get a more youthful skin appearance! Probably not a beginner product though.