10 Best Microneedling Serum

Selecting the best microneedling serum can dramatically enhance your results, helping to maximize collagen production and address specific skin concerns. As microneedling creates thousands of micro-channels in your skin, the serums you choose to apply before or after treatment can penetrate deeply for amplified benefits.

At Meamo, we've helped thousands of customers achieve remarkable transformations through our authentic Korean skincare innovations. Our expertly curated collection of microneedling serums combines cutting-edge ingredients with Seoul's advanced formulation techniques to deliver professional-grade results.

In this comprehensive guide, we'll explore the top microneedling serums available at MeamoShop, what makes them effective, and how to choose the right one for your skin type.

Table of Contents

Top 10 Serums & Skin Boosters for Microneedling Treatment

Microneedling treatment process

Key ingredients:

  • 1.3 billion nano-sized exosomes (30-100 nm) per ml
  • PDRN (Polydeoxyribonucleotide)
  • Sodium Hyaluronate (Hyaluronic Acid)

Benefits:

  • Stimulates natural collagen production through exosome signaling
  • Promotes skin repair and regeneration at the cellular level
  • Delivers deep hydration and enhanced elasticity

Pros:

  • Produces gradual, natural-looking results
  • Strengthens skin's structural foundation
  • Works synergistically with the skin's healing process

Cons:

  • Full results take time to develop (1-2 weeks)
  • Higher price point than some alternatives

Key ingredients:

  • Poly-L-Lactic Acid (PLLA)
  • PDRN (Polydeoxyribonucleotide)
  • Sodium Hyaluronate

Benefits:

  • Stimulates natural collagen production by activating fibroblasts
  • Promotes skin repair and regeneration
  • Delivers deep hydration and enhanced elasticity

Pros:

  • Produces gradual, natural-looking results
  • Strengthens skin's structural foundation
  • Works synergistically with the skin's healing process

Cons:

  • Full results take time to develop (2-3 weeks)
  • Higher price point than some alternatives

Key ingredients:

  • Poly-L-Lactic Acid (PLLA)
  • PDRN (Polydeoxyribonucleotide)
  • Vitamin C
  • Glutathione
  • Sodium Hyaluronate

Benefits:

  • Advanced collagen stimulation with brightening effects
  • Helps reduce pigmentation while regenerating skin
  • Provides immediate hydration and long-term rejuvenation

Pros:

  • Innovative INCUBE™ technology protects sensitive ingredients
  • Multifunctional: firms, brightens, and hydrates simultaneously
  • Visible improvements in skin texture and tone

Cons:

  • Premium pricing
  • May not be suitable for extremely sensitive skin
PLLA Cube PiNk VOL.

Key ingredients:

  • High-concentration Polynucleotide (PN)
  • Hyaluronic acid
  • Ultra-short Peptides
  • Niacinamide (Vitamin B3)
  • Growth factors

Benefits:

  • Superior skin regeneration with PN technology
  • Enhanced collagen and elastin production
  • Strengthens skin barrier while reducing redness

Pros:

  • Pharmaceutical-grade ingredients from HTL Biotechnology
  • Targets multiple concerns: wrinkles, redness, and pigmentation
  • Exceptional hydrating and firming properties

Cons:

  • Requires proper technique for optimal results
  • Premium investment

Key ingredients:

  • Poly-L-Lactic Acid (PLLA) microspheres
  • Sodium Carboxymethyl Cellulose (SCMC)
  • Biocompatible carriers

Benefits:

  • Long-lasting collagen production (up to 24 months)
  • Immediate smoothing effect from SCMC
  • Gradual volume restoration and skin rejuvenation

Pros:

  • Smart SPDS™ technology ensures uniform microspheres
  • Biocompatible and biodegradable
  • Offers both immediate and long-term benefits

Cons:

  • Professional application recommended
  • Results develop gradually over time
BEAUY Collagen Stimulator PLLA

Key ingredients:

  • 23% Polycaprolactone (PCL)
  • Peptides
  • Hydrating complexes

Benefits:

  • Powerful collagen stimulation for deep rejuvenation
  • Particularly effective for temples, neck, and under-eye areas
  • Significantly improves skin elasticity and texture

Pros:

  • Long-lasting results (up to 24 months)
  • Excellent for treating deep wrinkles
  • Superior firmness and tightening effects

Cons:

  • Higher viscosity requires a proper application technique
  • More suitable for moderate to advanced aging concerns

Key ingredients:

  • Specialized collagen-stimulating complex
  • Hydrating agents
  • Peptide technology

Benefits:

  • Enhanced skin firmness and elasticity
  • Improved appearance of fine lines and wrinkles
  • Comprehensive skin rejuvenation

Pros:

  • Designed specifically to complement microneedling
  • Helps restore skin's natural contours
  • Suitable for various facial areas

Cons:

  • Best results require multiple applications
  • Proper application technique is essential
CollareJu collagen stimulator

Key ingredients:

  • 150mg PDLLA (Poly-D, L-lactic Acid)
  • 50mg Hyaluronic acid
  • Proprietary carriers

Benefits:

  • Dual-action: immediate volumization and long-term collagen regeneration
  • Improves overall skin texture and firmness
  • Natural-looking volume restoration

Pros:

  • Smart SPDS™ Technology ensures consistent results
  • Balanced formula for multiple skin concerns
  • Combines the benefits of fillers and collagen stimulators

Cons:

  • Requires proper mixing technique
  • Professional application recommended

Key ingredients:

  • Polycaprolactone (PCL)
  • Hyaluronic acid
  • Peptide complex

Benefits:

  • Combined collagen stimulation and hydration
  • Reduces fine lines and wrinkles
  • Improves skin elasticity and firmness

Pros:

  • Long-lasting results (up to 12 months)
  • Balanced formulation for multiple concerns
  • Suitable for various facial areas

Cons:

  • Results develop gradually
  • May require multiple sessions for optimal outcomes

Key ingredients:

  • Specialized brightening complex
  • Hydrating molecules
  • Skin-firming peptides

Benefits:

  • Targets uneven skin tone and hyperpigmentation
  • Provides hydration while enhancing skin radiance
  • Supports skin's post-microneedling recovery

Pros:

  • Excellent for addressing discoloration
  • Creates glowing skin with improved texture
  • Complementary to microneedling's collagen-boosting effects

Cons:

  • Specialized formulation best for specific concerns
  • Requires consistent use for optimal results

Disclaimer: Individual results may vary. Professional advice is recommended.

What Makes a Serum Good for Microneedling?

The best microneedling serum should contain ingredients that work synergistically with the treatment to enhance healing, stimulate collagen, and address specific skin concerns. Key factors include:

  1. Growth factors - These powerful ingredients naturally occur in your skin and help regulate cell growth and stimulate collagen production. When applied after microneedling, they can significantly accelerate healing and enhance results.
  2. Hyaluronic acid - This hydrating molecule can hold up to 1000 times its weight in water. After microneedling, hyaluronic acid serum can penetrate deeply into the skin, providing intense hydration and plumping effects that improve skin texture.
  3. Peptides - These amino acid chains signal your skin to produce more collagen. When used with microneedling, they can amplify the collagen-stimulating effects of the treatment for smoother skin.
  4. Safe, non-irritating formulations - The ideal face serum should be free from potential irritants like fragrances, alcohols, and harsh chemicals that could cause inflammation in freshly treated skin.
  5. Stability and purity - High-quality ingredients in stable formulations ensure the active components remain effective when applied to the skin, maximizing benefits.
  6. Brightening agents - Ingredients like vitamin C, glutathione, and niacinamide can help address uneven skin tone and pigmentation when delivered deeper into the dermis through micro-channels.

How to Choose the Best Microneedling Serum for Your Skin Type

Different skin types require different approaches when selecting microneedling serums:

For Dry or Dehydrated Skin

Look for serums rich in hyaluronic acid and hydrating compounds like Miracle H, which provide intense moisture while supporting skin repair and improving skin texture.

For Aging Skin

Choose collagen-stimulating products like PLLA Cube, BEAUY, or Rejuner Black, which specifically target elastin production and structural improvements to address fine lines and wrinkles.

For Uneven Skin Tone

PLLA Cube PiNk VOL. with its combination of PLLA and brightening ingredients like glutathione and vitamin C can help address pigmentation concerns while stimulating collagen for more even skin tone.

For Sensitive Skin

Opt for gentle formulations with soothing ingredients that support the skin's healing process without causing irritation. Avoid products with potential sensitizers and look for serums that strengthen the skin barrier.

For Acne-Prone Skin

Look for non-comedogenic options with regenerative properties that can help improve skin texture without clogging pores. Ingredients that address both texture and appearance can be particularly beneficial.

Individual results may vary. Professional advice is recommended.

How to Use Serums After Microneedling Safely

To maximize benefits while minimizing potential side effects, follow these guidelines for using microneedling serums:

  1. Wait for the appropriate time: Allow 2-4 hours after treatment or until pinpoint bleeding has completely stopped before applying any serum.
  2. Apply with clean hands: Ensure your hands are thoroughly washed before touching your freshly treated skin to prevent contamination.
  3. Use gentle pressure: Pat, don't rub the serum into your skin to avoid irritation of the micro-channels created by tiny needles.
  4. Start with a small amount: A pea-sized amount is typically sufficient for the entire face to enhance penetration without overwhelming the skin.
  5. Follow with appropriate moisturizer: After the serum has absorbed, apply a gentle, non-comedogenic moisturizer to seal in the active ingredients and protect your skin barrier.
  6. Avoid certain ingredients immediately after treatment: Retinol, high-concentration vitamin C, retinoids, alpha hydroxy acids, beta hydroxy acids, and fragranced products should be avoided for at least 5-7 days after treatment.

BEAUY Collagen Stimulator (PLLA)

(29)
Original price was: $139.00.Current price is: $111.00.
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BEAUY is a next-generation powder-type collagen stimulator made with PLA and SCMC, designed to stimulate natural collagen production for long-lasting volume and skin rejuvenation. With its biodegradable microspheres and smooth injection properties, BEAUY offers a safe, effective alternative to traditional fillers—delivering results that can last up to 24 months.
Under-eye area Perfect spherical shape Uniform microspheres ensure smooth application, consistent performance, and natural results.
Wrinkle removal Ease of preparation Freeze-dried powder dissolves quickly, reducing prep time and streamlining treatments.
Safe formula Biodegradable Components Made from PLA polymer that fully decomposes in the body through natural metabolism.

BEAUX Collagen Stimulator (PDLLA/HA)

(30)
Original price was: $129.00.Current price is: $103.00.
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BEAUX is a cutting-edge powder-type collagen stimulator that combines 150 mg of PDLLA (Poly-D,L-lactic Acid) with 50 mg of Hyaluronic Acid (HA) to deliver both immediate volumizing effects and long-term collagen regeneration. Designed with Smart SPDS™ Technology, BEAUX microspheres are perfectly spherical and uniformly sized, ensuring consistent decomposition and exceptional safety.
Under-eye area Perfect spherical shape Uniform microspheres ensure smooth application, consistent performance, and natural results.
Wrinkle removal Ease of preparation Freeze-dried powder dissolves quickly, reducing prep time and streamlining treatments.
Safe formula Biodegradable Components Made from PDLLA polymer that fully decomposes in the body through natural metabolism.

Rejuner Black

(5)
Price range: $95.50 through $349.50
Earn up to 51 Points
Select options This product has multiple variants. The options may be chosen on the product page
Rejuner Black is a cutting-edge skin booster designed to stimulate collagen production and achieve deep skin rejuvenation, particularly for areas like the temples, neck, and under eyes.
  • High Concentration of PCL: Contains 23% polycaprolactone, which boosts rejuvenation and delivers noticeable results.
  • Long-Lasting Results: Effects can last up to 24 months, significantly improving skin elasticity and texture.
  • Collagen Stimulation: Enhances neocollagenesis, effectively reducing deep wrinkles and tightening the skin.

Rejuner Gold

(3)
Price range: $95.50 through $349.50
Earn up to 51 Points
Select options This product has multiple variants. The options may be chosen on the product page
Rejuner Gold is a premium skin booster designed to enhance skin rejuvenation and hydration through advanced collagen stimulation.
  • High Concentration of PCL: Contains 23% polycaprolactone, which boosts rejuvenation and delivers noticeable results.
  • Long-Lasting Results: Effects can last up to 24 months, significantly improving skin elasticity and texture.
  • Collagen Stimulation: Enhances neocollagenesis, effectively reducing deep wrinkles and tightening the skin.

What Are the Benefits of Serums for Post-Treatment?

Using the right serum after microneedling can significantly enhance your results through:

  1. Enhanced product absorption: The micro-channels created during treatment allow serums to penetrate deeply into the skin, increasing their efficacy by up to 300% and delivering nutrients to skin cells more effectively.
  2. Accelerated healing process: Ingredients like growth factors, centella asiatica, and peptides can speed up the skin's natural healing process, reducing downtime and improving comfort.
  3. Amplified collagen production: While microneedling itself stimulates collagen, the right serum can further enhance this effect for more dramatic improvements in skin texture and firmness.
  4. Targeted treatment for specific skin concerns: Whether you're addressing wrinkles, hyperpigmentation, or uneven texture, specialized serums can target your unique needs for personalized results.
  5. Protection against environmental damage: Certain serums contain antioxidants that protect newly exposed skin from environmental stressors, preserving the long-term benefits of your treatment.
  6. Extended treatment benefits: Proper serum use can prolong and enhance the results of each microneedling session, potentially reducing the number of treatments needed for optimal outcomes.

Individual results may vary. Professional advice is recommended.

Also read:

Snow Flower Bloom

$99.80
Earn 13 Points
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The Snow Flower Bloom skin booster, with its combination of beneficial ingredients, offers a holistic approach to skincare by addressing multiple skin concerns simultaneously, resulting in healthier, more youthful-looking skin. The Snow Flower Bloom procedure is recommended for individuals looking to repair and moisturize their skin, even out its tone, and diminish age spots resulting from sun exposure. It is particularly beneficial for post-treatment skin recovery after cosmetic procedures.
  • Facial Skin Regeneration: The Snow Flower Bloom skin booster provides a comprehensive solution for facial skin regeneration. It helps in repairing and rejuvenating the skin, enhancing its overall health and vitality.
  • Moisturization: This skin booster is formulated to deeply moisturize the skin, addressing dryness and promoting hydration. The presence of Hyaluronic Acid helps in retaining moisture, leading to softer and supple skin.
  • Skin Whitening & Tone Evenness: The inclusion of Glutathione in the Snow Flower Bloom skin booster offers a skin whitening effect, helping to even out the skin tone and reduce age spots caused by sun exposure. This leads to a brighter and more uniform complexion.

Miracle H

(22)
Price range: $69.00 through $279.00
Earn up to 40 Points
Select options This product has multiple variants. The options may be chosen on the product page
Miracle H Skin Booster blends PCL for collagen production and Hyaluronic Acid for hydration, significantly reducing wrinkles and firming skin. Enjoy smoother, tighter skin for up to a year after treatment.
  • Enhanced Skin Hydration: The combination of PCL and hyaluronic acid in the Miracle H Skin Booster provides deep hydration to the skin, ensuring optimal moisture levels for a healthy and radiant complexion.
  • Collagen Stimulation: PCL in the formula stimulates collagen production, helping to improve skin elasticity, reduce fine lines, and combat sagging skin, resulting in firmer and more youthful-looking skin.
  • Anti-Aging Effects: By fighting fine lines and sagging skin through collagen stimulation and providing intense hydration with hyaluronic acid, the Miracle H Skin Booster offers powerful anti-aging effects, promoting a smoother and more rejuvenated appearance.

Jeunetique EXO

(109)
Price range: $38.40 through $151.20
Earn up to 22 Points
Select options This product has multiple variants. The options may be chosen on the product page

 Download Brochure

An innovative skinbooster based on the rejuvenating action of exosomes at the subcellular level. The action of Meamo Jeunetique Exo is based on the introduction of active signaling molecules into the dermis using exosomes. The anti-aging properties of Meamo Jeunetique Exo are enhanced by the inclusion of polydesoxyribonucleotide (PDRN), atelocollagen, cellular growth factors and ultra-short peptides.
Exosomes Icon Exosomes Enhance cellular communication, accelerating skin repair and reducing inflammation.
PDRN Icon PDRN Drives deep cellular regeneration, renewing and revitalizing your complexion.
Collagen Regeneration Icon Collagen & Peptides Boost elasticity and hydration, smoothing fine lines and restoring firmness.

Curenex

(46)
$95.50
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The Curenex Intense Glow & Shine PDRN Skin Booster offers a comprehensive solution to maintain the youthful and vibrant appearance of the skin. Its main benefits include:

  • Cell Regeneration: PDRN stimulates cell regeneration, promoting the renewal and revitalization of the skin from within. Supports the skin's natural rejuvenation processes, contributing to a more youthful and refreshed appearance.
  • Collagen Production and Brightening: The inclusion of multiple kinds of Peptides boosts the skin's collagen production, enhancing skin structure and firmness. Peptides also work to brighten the skin tone, promoting a more radiant and even complexion.
  • Multi-Ingredient Formulation: Combines more than 20 ingredients, offering a comprehensive and all-in-one solution for skin rejuvenation and maintenance. Designed for overall skin health and vitality, especially when there isn't a single pronounced problem, but a desire to maintain a youthful and vibrant skin appearance.

Frequently Asked Questions

What serums should not be used with microneedling?

Immediately after microneedling treatment, avoid serums containing:

  • Retinol or retinoids
  • High concentrations of vitamin C (L-ascorbic acid)
  • Alpha and beta hydroxy acids (AHAs/BHAs)
  • Fragrance or essential oils
  • Potentially irritating active ingredients or chemicals

These ingredients can cause irritation, inflammation, or even damage when applied to freshly treated skin with microscopic needles. Wait at least 5-7 days before reintroducing these ingredients into your routine.

How soon can you apply serum after treatment?

For professional microneedling, it's generally recommended to wait 2-4 hours or until all pinpoint bleeding has stopped before applying any serum. For at-home devices with shorter needles, you may be able to apply appropriate serums immediately, but always follow the specific instructions for your device and depth setting to protect your skin barrier.

How often should you use microneedling serum?

The frequency depends on both your skin type and the specific serum:

  • Post-treatment serums: Apply as directed, typically 1-2 times daily for the first week after microneedling
  • Maintenance serums: Use according to product instructions, generally daily or several times weekly between microneedling sessions
  • Collagen-stimulating serums: These often have specific protocols based on their formulation, so follow the product guidelines

Regular application helps maintain results and supports your skin between microneedling treatments.

Are expensive serums better for microneedling?

Not necessarily. While premium serums often contain higher concentrations of active ingredients and advanced delivery systems, the best serum for you depends on your specific skin concerns, skin type, and treatment goals.

Quality and ingredient formulation matter more than price alone. Look for scientifically-backed ingredients in stable formulations from reputable manufacturers rather than focusing solely on price point. Board-certified dermatologists often recommend focusing on ingredient quality rather than cost alone.

What Are the Best Ingredients to Look For?

When choosing microneedling serums, prioritize these powerful ingredients:

  1. Hyaluronic acid - For deep hydration and plumping effects
  2. Peptides - To signal collagen production and improve firmness
  3. Growth factors - To accelerate healing and cellular regeneration
  4. Niacinamide - For brightening and strengthening the skin barrier
  5. Centella asiatica - To calm irritation and support healing
  6. Aloe vera - For soothing and hydrating sensitive skin
  7. Vitamin C (in appropriate formulations) - For antioxidant protection and brightening
  8. Snail mucin - For intense hydration and skin repair

These ingredients help maximize the benefits of microneedling while supporting your skin's recovery process.

End Note

The best microneedling serum can transform your results from good to extraordinary by working synergistically with your skin's natural healing process. The products featured in this guide represent the cutting edge in skin rejuvenation technology, offering solutions for every skin type and concern.

At MeamoShop, we're committed to bringing you authentic Korean skincare innovations that deliver professional-grade results. Whether you're addressing signs of aging, uneven skin tone, or simply want to maintain glowing skin, the right microneedling serum can help you achieve your skin goals faster and more effectively.

Remember to always patch test new products, follow proper aftercare guidelines, and consult with a skincare professional if you have any concerns about incorporating these serums into your microneedling routine.

Shop our complete microneedling collection to find the perfect serum for your skin needs and enjoy the transformation that comes from combining the best microneedling serums with this powerful skin rejuvenation technique. Use the discount code meamoblog for 12.5% off your purchase!

References:

  1. https://pmc.ncbi.nlm.nih.gov/articles/PMC11499218/

  2. https://www.mdpi.com/2079-9284/11/2/51

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