Rejuran Skin Booster

Tired of dull, aging skin that doesn't respond to serums anymore? Rejuran skin booster, developed in South Korea using salmon DNA, works at the cellular level to repair and regenerate skin from within. This regenerative skin booster delivers real improvements in skin texture, hydration, and overall skin health. Here's what you need to know before your first treatment.

Quick Summary

  • Rejuran uses polynucleotides (PN/PDRN) derived from salmon DNA to stimulate collagen production and skin regeneration.
  • Results typically appear within 2-4 weeks, with optimal results after 3-4 sessions spaced 3-4 weeks apart.
  • Effects last 6-12 months, with maintenance treatments recommended annually.
  • Best results occur in patients aged 30-50 with early signs of aging or dehydrated skin.
  • The full treatment series costs $1,200- $4,800, depending on the location.
  • Authentic product verification matters—counterfeit products have been reported.

Table of Contents

What Is Rejuran Skin Booster?

Rejuran is a skin booster treatment developed by PharmaResearch Co., Ltd. in South Korea. It contains polynucleotides (PN) and polydeoxyribonucleotides (PDRN) extracted from salmon DNA using their patented DNA Fragments Optimizing Technology (DOT™).

Unlike hyaluronic acid fillers that add volume, Rejuran skin booster activates your skin's natural healing processes. The polynucleotides stimulate fibroblasts—the cells responsible for natural collagen production. This leads to genuine skin regeneration rather than temporary plumping, resulting in improved skin texture and a more youthful appearance.

Rejuran has been KFDA-approved in South Korea since its development and gained massive popularity across Asia. The treatment is sometimes referred to as "salmon DNA therapy" due to its regenerative effects on skin tone and overall appearance.

How Does This Treatment Work?

Rejuran skin booster works through three cellular mechanisms to enhance skin health.

  • Cellular regeneration: Polynucleotides activate adenosine A2A receptors, triggering increased fibroblast activity and cellular turnover to stimulate skin regeneration.
  • Collagen stimulation: Activated fibroblasts produce more collagen and elastin, improving skin elasticity. Research confirms that polynucleotides effectively stimulate collagen synthesis and collagen production. This boost improves elasticity and reduces fine lines.
  • Anti-inflammatory effects: Rejuran helps reduce inflammation by activating adenosine receptors, making it effective for sensitive, damaged skin and post-procedure recovery. It works to smooth out uneven skin tone and discoloration.

Important: Results take 2-4 weeks to show. Full results appear after completing the treatment series.

What Are The Different Types of Rejuran Treatments?

PharmaResearch offers several Rejuran formulations to address specific skin concerns and rejuvenation goals.

Product

Best For

Key Features

Rejuran Healer

Overall skin rejuvenation

Medium viscosity; improves skin texture and hydration

Rejuran S

Acne scars and texture

Highest viscosity; healing essence for scar treatment

Rejuran I

Under-eye area

Lowest viscosity; addresses pigmentation and fine lines

Rejuran HB

Hydration + comfort

Contains hyaluronic acid and lidocaine for enhanced skin hydration

a woman with dry skin

What Is The Rejuran Treatment Technique?

Rejuran skin booster is typically administered via superficial intradermal delivery with fine needles (32G or 34G), ensuring even distribution throughout the treatment area.

The procedure process

  1. Consultation – Skin assessment and treatment planning
  2. Cleansing – Preparation of treatment area
  3. Numbing – Numbing cream applied for 20-40 minutes
  4. Administration – Small amounts delivered into the dermis at 0.5-1 cm intervals
  5. Post-care – LED therapy may reduce mild redness and inflammation

The procedure takes 30-60 minutes. Rejuran skin booster tends to be more uncomfortable than HA-based skin boosters due to its viscosity.

Pro tip: Request 34G needles if you have sensitive skin—reduces trauma by approximately 40%.

Rejuran HB

What Results Can You Expect From Rejuran?

Understanding the timeline helps set proper expectations for this skin booster treatment.

Week-by-week progression

  • Days 1-3: Mild redness, swelling, and bumps at treatment points. Resolves within 1-3 days (recovery process).
  • Weeks 1-2: Initial hydration and texture improvement. Skin feels softer with hydration improvements.
  • Weeks 2-4: Visible improvement in skin elasticity and fine lines. Pores appear refined with improved skin tone.
  • Weeks 4-12: Continued improvement as collagen synthesis progresses. Skin reveals a radiant, youthful appearance.

Research confirms polynucleotide treatments effectively improve skin texture, reduce wrinkles, and improve elasticity.

Important: Effects are cumulative—each treatment builds on the previous one for optimal results.

What Are the Advantages of Rejuran Skin Booster?

woman face wrinkles before and after treatment

Proven benefits

  • Collagen production and elastin stimulation for firmer, resilient skin
  • Enhanced skin hydration and moisture retention for radiant skin
  • Pore minimization and refined skin texture
  • Fine lines and wrinkles reduction without volume changes
  • Accelerated natural healing post-procedure
  • Skin barrier strengthening for protection against environmental damage

Rejuran skin booster also provides growth factors that support ongoing skin rejuvenation.

Who sees the best results?

  • Adults aged 30-50 with early signs of aging
  • Those with dehydrated, dull skin seeking improved skin health
  • Patients with thin skin or loss of skin elasticity
  • People recovering from laser treatments (aesthetic treatments)
  • Those with mild acne scarring or uneven skin tone

What Are The Side Effects of Rejuran Treatment?

Rejuran skin booster has an excellent safety profile when administered properly. The most common side effects are mild and temporary with minimal adverse effects.

Common side effects (expected)

  • Mild redness and swelling – Resolves within 24-48 hours
  • Small bumps – Flatten within 1-3 days as the healing essence absorbs
  • Mild bruising – Fades within 5-7 days
  • Tenderness – Subsides within 24 hours

Rare side effects (seek medical attention)

  • Persistent swelling or pain worsening after 48 hours
  • Signs of infection (heat, pus, fever)
  • Allergic reaction (hives, difficulty breathing)

Rejuran is derived from salmon DNA, which shares similarities with human DNA. While polynucleotides are 94-97% biocompatible with human tissue, those with severe seafood allergies should exercise caution.

What Is The Recovery Time After Rejuran?

One of Rejuran skin booster's advantages is minimal downtime. Most patients return to normal activities immediately.

Timeframe

What to Expect

Immediately after

Raised bumps visible at treatment points

2-4 hours

Bumps begin flattening as healing essence absorbs

24 hours

Mild redness subsides; makeup can be applied

1-3 days

Swelling resolves completely

5-7 days

Any bruising fades

The recovery process may take slightly longer for under-eye treatments or sensitive skin.

What To Avoid After Rejuran Treatment?

Proper post-care significantly impacts your results and skin health.

First 24-48 hours

  • No makeup for at least 24 hours
  • No touching or massaging the treatment area
  • No strenuous exercise or activities causing sweating
  • No hot showers, saunas, or steam rooms
  • Avoid prolonged sun exposure while the skin is healing.

First week

  • Avoid retinol, AHAs, BHAs, and vitamin C serums – These increase inflammation
  • Use physical sunscreen only – Chemical sunscreens penetrate deeper post-treatment
  • Skip harsh cleansers – Use gentle products to support skin barrier recovery
  • Avoid excessive sun exposure to prevent pigmentation issues

Critical warning

Combining Rejuran with acid-based products too soon causes contact dermatitis. Wait at least one week before resuming active skincare ingredients.

Selastin TOX

(26)
Price range: $27.00 through $89.00
Earn up to 4 Points
Select options This product has multiple variants. The options may be chosen on the product page
Selastin Tox is an innovative skin booster infused with Acetyl Hexapeptide-8, renowned for its tox-like effects. This potent formula is designed to lift, tighten, and deeply moisturize the skin, effectively minimizing the appearance of fine lines and wrinkles.
  • Lifting and Firming: Selastin Tox, powered by acetylhexapeptide-8, offers a lifting effect akin to Botox, tightening and firming the skin for enhanced elasticity.
  • Smooth and Elastic Skin: By working similarly to botulinum toxin, Selastin Tox helps in smoothening and rejuvenating the skin, promoting a more elastic and youthful appearance.
  • Protection from Oxidative Stress: This product safeguards the skin from reactive oxygen species, supporting overall skin health and vitality.

Puri PDRN

(1)
$79.00
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Puri PDRN is an advanced skin-boosting formula designed to support skin hydration, smoothness, and overall skin quality. Formulated with PDRN, Hyaluronic Acid, and Niacinamide, it helps improve the look of tired, uneven, or dehydrated skin while supporting a healthier, more radiant appearance over time. This formula focuses on enhancing skin quality rather than adding volume, making it suitable for those looking to refine texture and restore vitality.
  • Improved Skin Smoothness: Helps refine skin texture and reduce the appearance of roughness for a smoother, more even-looking complexion.
  • Deep Hydration & Lasting Moisture: Hyaluronic Acid attracts and retains moisture, supporting long-lasting hydration and a naturally plump appearance.
  • Enhanced Radiance & Skin Quality: Supports skin renewal and brightness, helping skin look fresher, healthier, and more luminous over time.

Curenex

(53)
$95.50
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The Curenex Intense Glow & Shine PDRN Skin Booster offers a comprehensive solution to maintain the youthful and vibrant appearance of the skin. Its main benefits include:

  • Cell Regeneration: PDRN stimulates cell regeneration, promoting the renewal and revitalization of the skin from within. Supports the skin's natural rejuvenation processes, contributing to a more youthful and refreshed appearance.
  • Collagen Production and Brightening: The inclusion of multiple kinds of Peptides boosts the skin's collagen production, enhancing skin structure and firmness. Peptides also work to brighten the skin tone, promoting a more radiant and even complexion.
  • Multi-Ingredient Formulation: Combines more than 20 ingredients, offering a comprehensive and all-in-one solution for skin rejuvenation and maintenance. Designed for overall skin health and vitality, especially when there isn't a single pronounced problem, but a desire to maintain a youthful and vibrant skin appearance.

Laetigen

$249.80
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Laetigen Collagen Skin Rejuvenation is an advanced dermal treatment designed to restore skin elasticity, firmness, and natural radiance. Formulated with high-purity Type I collagen, it replenishes structural proteins directly within the skin, helping improve hydration, texture, and overall skin vitality. By supporting collagen regeneration, Laetigen promotes smoother, firmer, and more youthful-looking skin. Ideal for those seeking professional-grade anti-aging care focused on restoring skin density and long-lasting glow.
  • Improved Skin Elasticity: Helps restore firmness and structural support within the skin, reducing the appearance of sagging and loss of elasticity.
  • Enhanced Hydration & Radiance: Supports moisture retention and improves skin tone, leaving the skin looking refreshed and luminous.
  • Smoother Skin Texture: Helps refine the appearance of pores and fine lines while promoting a more even and youthful complexion.
  • Long-Lasting Skin Revitalization: Encourages natural collagen regeneration, allowing results to improve gradually with repeated treatments.

How Much Does Rejuran Cost?

Rejuran skin booster pricing varies by location, provider, and number of sessions for optimal results.

Price ranges by region

Location

Per Session

Full Series (3-4 sessions)

South Korea

$250-$420

$750-$1,680

Singapore

$450-$500

$1,350-$2,000

United States

$500-$1,200

$1,500-$4,800

Hidden costs to consider

  • Consultation fees – $75-$150 (may not be waived)
  • Numbing cream – $20-$50 (if not included)
  • Post-treatment LED therapy – $50-$150 (optional for skin rejuvenation)
  • Maintenance sessions – $300-$1,200/year
  • Additional variants – Priced separately (Rejuran Healer, tone up booster)

Unusually low prices can signal potential issues with product authenticity.

How Many Rejuran Sessions Are Needed For the Best Results?

The standard protocol involves multiple sessions for optimal skin rejuvenation results.

Initial course: 3-4 sessions spaced 3-4 weeks apart

Maintenance: 1 session every 6-12 months to maintain overall skin health

Rejuran skin booster effects are cumulative. Each treatment builds on the previous one to enhance skin texture and hydration. Patients completing 3+ treatments report significantly higher satisfaction with skin quality and youthful appearance.

Full benefits typically appear within several weeks after completing the series, revealing improvements in skin tone and overall appearance.

Disclaimer: Individual results vary based on skin condition, age, and adherence to treatment protocols.

How Does Rejuran Compare To Other Skin Boosters?

Treatment

Primary Mechanism

Best For

Results Timeline

Rejuran

PN cellular regeneration

Skin repair, texture, skin elasticity

2-4 weeks, cumulative

Profhilo

HA bioremodeling

Hydration, mild laxity

Visible within days

Skinvive

Cross-linked HA

Hydration, smoothness

Visible within days

Juvelook

PDLLA + HA

Volume + collagen production

4-6 weeks

Dermal fillers

Volume restoration

Volume loss, deep wrinkles

Immediate

When to choose the Rejuran skin booster

  • You want skin quality and texture improvement rather than volume
  • You have damaged skin needing natural healing support
  • You're looking for skin rejuvenation and preventative anti-aging
  • You want to improve elasticity and enhance skin hydration long-term

How To Incorporate Skin Boosters Into A Practice

For practitioners adding Rejuran skin booster treatments in aesthetic medicine:

  • Storage requirements: Rejuran must be stored frozen (-5°C to -20°C) before first use, then refrigerated within 7 days of first use. This preserves essential nutrients and growth factors.
  • Patient selection: Best results in patients aged 30-50 with appropriate indications for skin rejuvenation.
  • Product authenticity: Source from reputable Korean suppliers to ensure authentic salmon DNA products for superior texture and hydration results.

MeamoShop offers a wholesale program featuring authentic skin booster products, including Rejuran, tone-up booster, and healing essence formulas.

Hanheal Exosome Facial Rejuvenation

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$149.00
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HANHEAL Exosome Facial Rejuvenation is an advanced skin-revitalizing formula designed to support hydration, skin vitality, and a refreshed appearance. Formulated with exosomes and hyaluronic acid, it helps improve the look of tired, dehydrated, and uneven skin, promoting a smoother, healthier-looking complexion. Ideal for those seeking next-level skin care focused on overall skin quality.
  • Solution ampoules: 5 mL × 5 vials
  • Dry (lyophilized) exosome powder: 100 mg × 5 vials
  • Improved Skin Smoothness:Helps refine the look of skin texture and reduce visible  roughness for a smoother, more even-looking complexion.
  • Deep Hydration & Natural Radiance: Supports moisture retention to enhance skin glow and overall skin quality.
  • Enhanced Overall Skin Vitality: Helps skin appear healthier, fresher, and more balanced over time.

Jeunetique NAD⁺

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Price range: $46.40 through $185.60
Earn up to 9 Points
Select options This product has multiple variants. The options may be chosen on the product page
Meamo Labs Jeunetique NAD⁺ is an advanced skin booster developed to restore skin vitality by targeting cellular energy and regeneration. Its uniqueness lies in the combination of NAD, NMN, and plant-derived exosomes, delivering a powerful anti-aging effect beyond traditional skin boosters. Here are the key aspects that make this product exceptional:
  • Cellular Energy & Skin Rejuvenation
    NAD and NMN support intracellular energy production, improving skin renewal and overall vitality.

  • Regeneration & Repair Activation
    Plant-derived exosomes deliver bioactive signals that stimulate repair processes and enhance skin resilience.

  • Hydration, Elasticity & Skin Quality
    Hyaluronic acid, peptides, and atelocollagen improve hydration, elasticity, and skin texture.

  • Recovery & Anti-Aging Support
    PDRN and growth factors help calm inflammation, accelerate recovery, and visibly reduce signs of aging.

 

BEAUX Collagen Stimulator (PDLLA/HA)

(36)
Original price was: $129.00.Current price is: $103.00.
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BEAUX is a cutting-edge powder-type collagen stimulator that combines 150 mg of PDLLA (Poly-D,L-lactic Acid) with 50 mg of Hyaluronic Acid (HA) to deliver both immediate volumizing effects and long-term collagen regeneration. Designed with Smart SPDS™ Technology, BEAUX microspheres are perfectly spherical and uniformly sized, ensuring consistent decomposition and exceptional safety.
Under-eye areaPerfect spherical shape Uniform microspheres ensure smooth application, consistent performance, and natural results.
Wrinkle removalEase of preparation Freeze-dried powder dissolves quickly, reducing prep time and streamlining treatments.
Safe formulaBiodegradable Components Made from PDLLA polymer that fully decomposes in the body through natural metabolism.

Regenovue Aquashine Plus

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$59.30
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Regenovue Aqua Shine Plus contains hyaluronic acid partially cross-linked by intermolecular bonds. It works slowly but gives very long lasting results. Regenovue Aqua Shine Plus is ideal for long-lasting and very deep hydration and rejuvenation of your skin.
  • Deep and Lasting Hydration: This skin booster provides long-lasting and deep hydration, ideal for rejuvenating the skin.
  • Cross-linked Hyaluronic Acid: It contains hyaluronic acid partially cross-linked by intermolecular bonds, which contributes to effective skin revitalization.
  • Gradual yet Long-Lasting Results: Despite its slow-acting nature, it delivers long-lasting and significant rejuvenating effects.

Who Is Not A Good Candidate For Rejuran Treatment?

Contraindications

  • Severe seafood allergy – Rejuran is derived from salmon DNA
  • Active skin infections – Wait until resolved
  • Pregnancy or breastfeeding – Insufficient safety data
  • Unrealistic expectations – Those expecting filler-like volume or immediate results

Limited benefit cases

  • Under 20 with healthy skin – Minimal improvement in skin texture
  • Over 50 with deep aging signs – May need combination aesthetic treatments
  • Severe scarring – May need more aggressive interventions

For those who cannot receive treatments, topical PN products like Rejuran Elaskin Essence offer a non-invasive alternative.

How Do You Choose The Right Provider for Rejuran Skin Booster Treatment?

Verification checklist

Before booking:

  • Confirm the clinic uses authentic, KFDA-approved Rejuran skin booster products
  • Ask about product storage (must be frozen before first use)
  • Verify provider training with polynucleotide treatments in aesthetic medicine

At your appointment:

  • Request to see the unopened product box
  • Check for MFDS license number (format: "제 2023-XXXXX")
  • Look for a hologram verifying authentic salmon DNA content

Red flags

  • Prices are significantly below the market rate
  • Unwillingness to show product packaging
  • No clear answers about product sourcing

Also read:

Frequently Asked Questions

Is Rejuran better than Botox?

No, they serve completely different purposes.

Botox relaxes muscles to reduce dynamic wrinkles. Rejuran skin booster regenerates skin cells, improving overall skin health and quality. They work well together as part of a comprehensive skin rejuvenation plan.

  • Choose Botox for: Forehead lines, crow's feet, and frown lines caused by muscle movement.
  • Choose Rejuran for: Skin texture, skin elasticity, hydration, and fine lines not related to muscle movement.

Is Rejuran better than filler?

They work differently and aren't directly comparable.

Dermal fillers add volume beneath the skin. Rejuran skin booster improves skin quality by stimulating natural collagen production and skin regeneration. Fillers provide immediate visible change; Rejuran provides gradual improvement in skin texture.

  • Choose dermal fillers for: Lost volume in cheeks, lips, or nasolabial folds; deep wrinkles.
  • Choose Rejuran for: Overall skin quality, fine lines, texture issues, and improving skin elasticity.

Many patients benefit from combining both dermal fillers for structure and Rejuran for skin rejuvenation.

Is Rejuran better than microneedling?

Rejuran typically produces more significant results, but at a higher cost.

Microneedling creates controlled micro-injuries to stimulate collagen production. Rejuran delivers polynucleotides at the cellular level to activate cellular regeneration. Both stimulate collagen synthesis, but through different mechanisms.

Choose microneedling for: Budget-friendly collagen stimulation; mild textural concerns.

Choose Rejuran for: More targeted skin regeneration; damaged skin needing natural healing support.

Why is Rejuran so expensive?

Several factors contribute to Rejuran skin booster's premium pricing:

  • Patented extraction technology – DOT™ extracts DNA fragments proprietary to PharmaResearch
  • Purification requirements – Polynucleotides derived from salmon must be highly purified
  • Cold-chain logistics – Requires frozen storage to preserve essential nutrients
  • Multiple sessions needed – Full course requires 3-4 treatments for optimal results
  • Training requirements – Proper administration requires specialized technique

What are the disadvantages of Rejuran?

Being transparent about limitations helps set realistic expectations.

  • Delayed results – Takes a few weeks to see improvement in skin texture
  • Multiple sessions required – Single treatments often disappoint
  • Cost – Full treatment series represents a significant investment
  • Temporary downtime – Bumps and mild redness for 1-3 days
  • Not volumizing – Won't replace lost facial volume like dermal fillers
  • Maintenance needed – Results fade after 6-12 months

The most common disappointment comes from patients who expect immediate transformation. Rejuran works gradually to enhance skin health—it's not a quick fix.

How can I verify whether my practitioner is using authentic Rejuran?

  1. Request to see the sealed box before treatment
  2. Check for the KFDA/MFDS license number in the format "제 2023-XXXXX."
  3. Look for the hologram sticker – Scratch to reveal verification code
  4. Ask about storage – Authentic Rejuran must arrive frozen
  5. Check batch number – Can be verified through PharmaResearch's portal

Warning signs of a fake product

  • No hologram or blurry hologram
  • Missing MFDS license number
  • Price is significantly below the market rate
  • Provider refuses to show the packaging

Can I combine Rejuran with my retinol routine?

Yes, but timing matters.

Retinol and active ingredients should be paused for at least one week after Rejuran treatment. The skin barrier is vulnerable during natural healing, and combining actives too early can trigger inflammation.

Safe timeline

  • Days 1-7: Gentle cleanser and moisturizer only; physical sunscreen
  • Week 2: Gradually reintroduce mild actives (vitamin C, niacinamide)
  • Week 3: Resume retinol at reduced frequency
  • Week 4+: Return to normal routine

Final Thoughts

Rejuran skin booster represents Korea's most innovative approach to skin regeneration. Working at the cellular level to stimulate collagen production and cellular repair can yield genuine improvements in skin quality. Salmon DNA-derived polynucleotides provide essential nutrients that enhance skin texture, hydration, and skin health.

Results take time, multiple sessions matter, and authentic products make the difference. For those willing to invest, Rejuran delivers improvements in texture, skin elasticity, and overall skin health—revealing resilient, radiant skin.

For authentic Korean Rejuran products, MeamoShop sources directly from Seoul. Our skin booster collection includes Rejuran Healer, healing essence variants, and tone-up booster options—all KFDA-approved.

Exclusive for blog readers: Use code MEAMOBLOG at checkout to save 12.5% on your order. Sign up for our inbox newsletter to receive updates on new products, sale prices, and exclusive discounts.

Disclaimer: The information provided is for educational use only. Licensed healthcare providers must perform Rejuran and similar skin booster treatments. Individual results vary based on skin condition, age, and adherence to treatment protocols. A healthcare provider can help determine if Rejuran is the right option for your specific situation.

Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC11311621/
[2] https://onlinelibrary.wiley.com/doi/10.1111/jocd.16721
[3] https://www.mdpi.com/2076-3417/15/19/10437

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