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MEAMO Labs Jeunetique NAD⁺
Next-generation skin booster that combines the anti-aging effects of plant-derived exosomes with a powerful cellular energy boost from nicotinamide adenine dinucleotide (NAD⁺).
Developed by MEAMO Labs, Jeunetique NAD⁺ is a next-generation skin booster that goes beyond hydration and stimulation. It reactivates cellular energy, accelerates regeneration, and delivers visible anti-aging results where standard boosters stop working.
What is MEAMO Labs Jeunetique NAD⁺?
Overview
MEAMO Jeunetique NAD⁺ is an ultimate skin revitalizer for rejuvenating and restoring the skin by naturally improving intracellular metabolism.
MEAMO Jeunetique NAD⁺ combines two powerful anti-aging components:
- Plant-derived exosomes – they deliver signaling molecules into the dermis, activating reparative processes.
- NAD⁺ (Nicotinamide Adenine Dinucleotide) and NMN (Nicotinamide Mononucleotide) – substances essential for energy production in our cells.
The anti-aging effect of Meamo Jeunetique NAD⁺ is further enhanced by polydeoxyribonucleotides (PDRN), atelocollagen, growth factors, and ultra-short peptides.
Why Jeunetique NAD⁺ Redefines Skin Rejuvenation
- NAD⁺ Therapy — Energy at the Cellular Level
Jeunetique NAD⁺ directly addresses one of the key drivers of skin aging: age-related NAD⁺ depletion.
After 40, cellular energy drops dramatically — fibroblasts slow down, collagen production declines, and skin loses firmness.
Jeunetique NAD⁺ restores metabolic activity where anti-aging truly begins: inside the cell. - Dual NAD⁺ System: NAD⁺ + NMN
• Immediate metabolic activation from NAD⁺
• Sustained intracellular replenishment via NMN
This combination delivers stronger, longer-lasting rejuvenation, especially in mature skin. - Plant-Derived Exosomes — Regeneration Signaling
Exosomes from ginseng, centella asiatica, and camellia japonica act as targeted messengers, activating repair, renewal, and intercellular communication in the dermis.
- Multi-Layer Anti-Aging Formula
Jeunetique NAD⁺ is not a single-ingredient booster. It combines:
• NAD⁺ & NMN — cellular energy
• Exosomes — regeneration signaling
• PDRN — tissue repair
• Atelocollagen & Hyaluronic Acid — structure and hydration
• Growth Factors & Ultra-Short Peptides — collagen stimulation and wrinkle reduction
One Injection. Multiple Anti-Aging Pathways.
Where Jeunetique NAD⁺ Wins Clinically
Designed for 40+ Skin
Standard exosome or HA-based boosters are often insufficient after NAD⁺ decline begins. Jeunetique NAD⁺ is specifically engineered for mature, tired, post-procedure, and damaged skin.
Ideal for:
- Loss of firmness and elasticity
- Wrinkles and skin laxity
- Post-peel and post-procedure recovery
- Photoaging and dull complexion
- Regenerative protocols and premium anti-aging courses
Components of MEAMO Jeunetique NAD⁺
Key active ingredients:
-
Nicotinamide adenine dinucleotide (NAD⁺)
– a vital coenzyme present in all living cells. It plays a central role in producing cellular energyNavas, L.E., Carnero, A. NAD+ metabolism, stemness, the immune response, and cancer. Nature. Signal Transduction and Targeted Therapy, 6, 2 (2021).
-
Nicotinamide mononucleotide (NMN)
– a precursor to NAD⁺ with the highest availability for our tissues. Moreover, it has shown the best safety profile among all NAD⁺ precursors, with no side effects reported even after 12 months of administration.Vinten, K.T., Trętowicz, M.M., Coskun, E. et al. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. Nature Metabolism 7, (2025).
-
Exosomal vesicles isolated from callus cells
– the plant equivalent of stem cells. We obtain them from three medicinal plants:
● Panax ginseng (Panax Ginseng);
● Centella asiatica (Centella Asiatica);
● Camellia japonica (Camellia Japonica).Karabay, A. Z., Barar, J., Hekmatshoar, Y. Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery. Biomolecules, 2025, 15(3), 394.
- PDRN (polydeoxyribonucleotide) – DNA extracted from salmon sperm. PDRN has anti-inflammatory and regenerative effects.
Khan A., Wang G., Zhou F., et al. Polydeoxyribonucleotide: A promising skin anti-aging agent. Journal of Plastic and Reconstructive Surgery. Volume 4, Issue 4, December 2022, p. 187–193.
- Atelocollagen – a highly purified protein used to deliver nucleic acids, proteins, and other signaling molecules into cells.
Fujimoto I., Takei Y. Atelocollagen-mediated siRNA delivery: future promise for therapeutic application. Therapeutic Delivery. 2014 Apr;5(4):369–371.
- Hyaluronic acid – essential for skin hydration. Each molecule of hyaluronic acid can hold up to 21 water molecules. Age-related loss of hyaluronic acid contributes to skin aging and wrinkles.
Humzah D., Molina B., Salti G., et al. Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine? International Journal of Molecular Sciences. 2024;25(6):3216.
- Ultra-short peptides – short peptide molecules that reduce wrinkles and hyperpigmentation, stimulate collagen synthesis, and inhibit elastin degradation. By penetrating the muscular layer, they also provide a local muscle-relaxing effect, earning them the name “Botox-like peptides.”
Wongrattanakamon P., Nimmanpipug P., Sirithunyalug B., Jiranusornkul S. Molecular modeling elucidates the cellular mechanism of synaptotagmin–SNARE inhibition: a novel plausible route to anti-wrinkle activity of botox-like cosmetic active molecules. Molecular and Cellular Biochemistry. 2018;442(1–2):97–109.
- Growth factors – EGF (epidermal growth factor), FGF (fibroblast growth factor), and IGF (insulin-like growth factor), which accelerate the production of collagen and elastin in skin cells.
de Araújo R., Lôbo M., Trindade K., et al. Fibroblast Growth Factors: A Controlling Mechanism of Skin Aging. Skin Pharmacology and Physiology. 2019;32(5):275–282.
What is the difference between Meamo Jeunetique NAD⁺ and Meamo Jeunetique Exo?
When to use these products?
Indeed, the compositions of these skin boosters are similar in many ways. Therefore, both can treat a range of skin problems:
- excessed skin dryness;
- oily skin;
- photoaging;
- pigmentation disorders;
- vascular defects (couperose);
- small scars and skin marks;
- forehead, periorbital, perioral wrinkles and other facial lines;
- cellulite;
- consequences of acne;
- diffuse hair loss, dandruff, split ends.
The main difference is that Meamo Jeunetique NAD⁺ contains NAD⁺ and NMN. These molecules are absolutely essential for energy metabolism in all cells of our body, including skin cells.
Betsuno, R., Yamane, T., Tsuji, H., et al. Permeation of Nicotinamide Mononucleotide (NMN) in an Artificial Membrane as a Cosmetic Skin Permeability Test Model. Journal of Cosmetic Dermatology, 2025, 24(5), e70222.
Rajman, L., Chwalek, K., Sinclair, D. A. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism, 2018, 27(3), 529–547.
With age, NAD⁺ levels in tissues fall significantly. By age 40, NAD⁺ production drops by 1.5 times compared to ages 18-20. By age 50, levels are roughly half of those in young adults.
When NAD⁺ is low, fibroblasts cannot make enough energy to perform functions like producing collagen and elastin – the main structural proteins of the skin. Consequently, the skin loses firmness and smoothness, wrinkles appear, it sags, and its texture deteriorates. Boosting NAD⁺ can slow these processes and restore youthful skin.
Research shows that introducing NAD⁺ at an age when its cellular levels are still sufficient is not beneficial. The greatest improvement is observed when NAD⁺ supplementation begins after its physiological level decline due to aging.
Covarrubias, A.J., Perrone, R., Grozio, A., et al. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021, 22, 119–141.
Abdellatif M., Sedej S., Kroemer G. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation, Volume 144, Number 22, November 2021.
Key takeaway!
- For maintaining healthy, youthful skin under 40, Meamo Jeunetique Exo may be a better choice.
- For rejuvenation after 40, and for aiding skin regeneration after damage or aggressive procedures, Meamo Jeunetique NAD⁺ is preferable.
Fang, E. F., Lautrup, S., Hou, Y., et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 2017, 23(10), 899–916.
How does MEAMO Jeunetique NAD⁺ work?
Mechanism of action
1. NAD+
2. NMN
3. Exosomes
1. NAD+
Energy production
NAD⁺ is a key component in the function of mitochondria, which produce energy in our cells. It transfers electrons in redox reactions, which are essential for all ATP-generating pathways: glycolysis, the Krebs cycle, and oxidative phosphorylation.
Regulation and signaling
NAD⁺ is essential for the activity of important enzymes, including sirtuins and PARP (poly-ADP-ribose polymerase). These enzymes are involved in:
- cellular aging and longevity maintenance;
- DNA repair after damage;
- regulation of sleep-wake cycles;
- immune response modulation.
Poljšak, B., Kovač, V., Špalj, S., Milisav, I. The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation.
International journal of molecular sciences, 2023, 24(3), 2959.
Aman Y., Qiu Y., Tao J. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging, Volume 2, 2018, Pages 30-37.
NAD⁺ and aging
NAD⁺ levels in the human body decline with age and with excessive body weight. Low NAD⁺ contributes to aging signs in skin, as this molecule is involved in controlling oxidative stress. Such stress is one of the most fundamental biochemical processes driving aging. Research shows that increasing NAD⁺ levels improves metabolic health and slows aging.
Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One. 2012;7:e42357.
2. NMN
In addition to NAD⁺ itself, its precursors, particularly nicotinamide mononucleotide (NMN), have demonstrated excellent anti-aging effects. NMN is converted into NAD⁺ with the help of the enzyme phosphoribosyltransferase.
Tooba I., Takashi N. The therapeutic perspective of NAD+ precursors in age-related diseases,
Biochemical and Biophysical Research Communications, Volume 702, 2024, 149590ю
3. Exosomes
Exosomes are small extracellular vesicles with a bilayer phospholipid membrane. They contain mRNA and DNA, lipids, ribosomal proteins, metabolic enzymes, ligands, cytoskeletal molecules, chaperone proteins, etc. These nanovesicles are stable, biocompatible, and minimally immunogenic. Because they fuse with recipient cell membranes, exosomes in Meamo Jeunetique NAD+ work as efficient targeted carriers. Their cargo can stimulate intercellular communication and activate pathways for tissue regeneration.
Moghassemi S, Dadashzadeh A, Sousa MJ, et al. Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade. Bioact Mater. 2024;36:126-156. Published 2024 Mar 2. doi:10.1016/j.bioactmat.2024.02.021
Haykal, D., Wyles, S., Garibyan, L. Exosomes in Cosmetic Dermatology: A Review of Benefits and Challenges. Journal of drugs in dermatology, 2025, JDD, 24(1), 12–18.
Preparing MEAMO Jeunetique NAD⁺ for use
Vial #1
Vial #2
Vial #1
Vial 1 contains 100 mg of lyophilized powder, which includes:
- NAD⁺ – 20%;
- NMN – 20%;
- Panax Ginseng Callus Exosomes – 18% (11 billion units);
- Centella Asiatica Callus Exosomes – 18% (1.1 billion units);
- Camellia Japonica Callus Exosomes – 18% (1 billion units);
- Sodium Hyaluronate – 6%.
Vial #2
Vial 2 contains 6 ml of a solution including PDRN, atelocollagen, ultra-short peptides, and cellular growth factors.
To prepare the solution:
- Open the aluminum cap and remove the rubber stopper from both vials.
- Draw the contents of vial 2 into a syringe
- Add it to vial 1.
- Gently dissolve the lyophilized powder with circular motions, avoiding bubbles.
Where and how to apply MEAMO Jeunetique NAD⁺?
- Meamo Jeunetique NAD⁺ is intended to reduce forehead lines, glabellar lines, crow’s feet, perioral lines, and nasolabial folds.
- Additionally, our skinbooster can be used to correct skin laxity and a double chin, and even out skin tone on the cheeks and other facial areas.
- MEAMO Jeunetique NAD⁺ has a local effect. This means it should be injected directly into the areas requiring correction of age-related concerns.
- Use ultra-fine needles for injections to minimize discomfort. Optimal needle sizes are 31G, 32G, and 33G with a 4 mm length.
- Injections should be performed superficially, into the subcutaneous layer. The needle angle should be 45 degrees, with the bevel facing upwards.
- Penetration depth: 1–1.5 mm.
- Injection points should be placed at the intersections of an imaginary grid composed of 1-cm-square cells.
Summary table of MEAMO Jeunetique NAD+ protocols
Treatment area | Injection volume |
|---|---|
Forehead Lines | |
Glabella | |
Crow's Feet | |
Perioral Area | |
Nasolabial Folds | |
Marionette Lines | |
Chin Area | |
Hyperpigmentation |
Post-treatment care after MEAMO Jeunetique NAD⁺ injections
For best results, advise patients to
- Avoid touching the treated area and do not apply cosmetics for 24 hours.
- Avoid heavy physical activities and do not visit pools, saunas, or tanning beds for one week.
- Do not use scrubs or peels on treated areas for one week.
- Refrain from smoking and alcohol consumption for one week.
Course protocol for MEAMO Jeunetique NAD⁺
Best results are achieved with a course of sessions. The exact number of sessions depends on the area requiring correction and the severity of wrinkles or other issues.
How quickly will the result appear?
NAD⁺ and NMN stimulate energy metabolism in cells, which is reduced due to age or damage. Exosomes deliver signaling molecules and growth factors into the skin, enhancing cellular regeneration and collagen synthesis. Together, they create a triple synergy for natural rejuvenation. You will notice changes within 1-2 days after the first injection session. During this time, NAD⁺ and NMN integrate into dermal energy metabolism. After a week, the effects will intensify as the skin cells begin responding to the signaling molecules and metabolites in the exosomes. Wrinkles will gradually smooth out, skin tone will evens out, and minor defects such as telangiectasias, couperose, and post-acne marks will start to fade.
The ingredients in MEAMO Jeunetique NAD⁺ work cumulatively, so the results will become more significant after each treatment. This will be particularly noticeable in the gradual tightening of the skin as a new collagen matrix forms.
What's Inside
Each Jeunetique NAD⁺ 2 vials (6 mL + 100 mg) pack includes:
- 1 vial (6 mL solution)
- 1 vial (100 mg powder)
Each Jeunetique NAD⁺ 1 box set includes:
- 5 vials (6 mL solution)
- 5 vials (100 mg powder)
FAQ
How to store MEAMO Jeunetique NAD⁺
- Store vials away from heat and open flames, in a cool, well-ventilated place.
- Keep out of direct sunlight.
- Storage temperature should not exceed 30°C (86°F).
- An opened vial should be stored in the refrigerator at 5-10°C (41-50°F) for no more than 7 days.
- Ensure the vial is always tightly closed.
Please note that our products are meant to be administered by medical professionals. We are not responsible for any negative inflictions that may arise after administering products by yourself. We will not compensate for products that have been wasted or misused.
References:
- Abdellatif М., Sedej S., Kroemer G. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. Volume 144, Number 22. November 2021.
- Aman Y., Qiu Y., Tao J. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging, Volume 2, 2018, Pages 30–37.
- Betsuno, R., Yamane, T., Tsuji, H., et al. Permeation of Nicotinamide Mononucleotide (NMN) in an Artificial Membrane as a Cosmetic Skin Permeability Test Model. Journal of Cosmetic Dermatology, 2025, 24(5), e70222.
- Conlon N. J. The Role of NAD+ in Regenerative Medicine. Plastic and Reconstructive Surgery, 2022, 150(4 Suppl), 41S–48S.
- Covarrubias, A.J., Perrone, R., Grozio, A., et al. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021, 22, 119–141.
- de Araújo, R., Lôbo, M., Trindade, K., et al. Fibroblast Growth Factors: A Controlling Mechanism of Skin Aging. Skin Pharmacology and Physiology, 2019, 32(5), 275–282.
- Fang, E. F., Lautrup, S., Hou, Y., et al. NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in Molecular Medicine, 2017, 23(10), 899–916.
- Fujimoto I., Takei Y. Atelocollagen-mediated siRNA delivery: future promise for therapeutic application. Therapeutic Delivery, 2014 Apr;5(4):369–371.
- Haykal, D., Wyles, S., Garibyan, L. Exosomes in Cosmetic Dermatology: A Review of Benefits and Challenges. Journal of Drugs in Dermatology, 2025, 24(1), 12–18.
- Huang, J., Cao, X., Wu, W., et al. Investigating the proliferative inhibition of HepG2 cells by exosome-like nanovesicles derived from Centella asiatica extract through metabolomics. Biomedicine & Pharmacotherapy, 2024, 176, 116855.
- Humzah D., Molina B., Salti G., et al. Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine? International Journal of Molecular Sciences, 2024 Mar 12;25(6):3216.
- Jacobson, E. L., Kim, H., et al. A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin. Experimental Dermatology, 2007, 16(6), 490–499.
- Karabay, A. Z., Barar, J., Hekmatshoar, Y. Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery. Biomolecules, 2025, 15(3), 394.
- Khan A., Wang G., Zhou F., et al. Polydeoxyribonucleotide: A promising skin anti-aging agent. Journal of Plastic and Reconstructive Surgery, Volume 4, Issue 4, December 2022, Pages 187–193.
- Massudi H., Grant R., Braidy N., et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 2012;7:e42357.
- Moghassemi S., Dadashzadeh A., Sousa M.J., et al. Extracellular vesicles in nanomedicine and regenerative medicine: A review over the last decade. Bioactive Materials, 2024;36:126–156.
- Nadeeshani, H., Li, J., Ying, T., et al. Nicotinamide mononucleotide (NMN) as an anti-aging health product: promises and safety concerns. Journal of Advanced Research, 2021, 37, 267–278.
- Navas, L.E., Carnero, A. NAD+ metabolism, stemness, the immune response, and cancer. Signal Transduction and Targeted Therapy, 2021, 6, 2.
- Poljšak, B., Kovač, V., Milisav, I. Current Uncertainties and Future Challenges Regarding NAD+ Boosting Strategies. Antioxidants (Basel), 2022, 11(9), 1637.
- Poljšak, B., Kovač, V., Špalj, S. The Central Role of the NAD+ Molecule in the Development of Aging and the Prevention of Chronic Age-Related Diseases: Strategies for NAD+ Modulation. International Journal of Molecular Sciences, 2023, 24(3), 2959.
- Rajman, L., Chwalek, K., Sinclair, D. A. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism, 2018, 27(3), 529–547.
- Song Q., Zhou X., Xu K., et al. The safety and anti-aging effects of nicotinamide mononucleotide in human clinical trials: an update. Advances in Nutrition, 2023, 14(6), 1416–1435.
- Tooba I., Takashi N. The therapeutic perspective of NAD+ precursors in age-related diseases. Biochemical and Biophysical Research Communications, Volume 702, 2024, 149590.
- Vinten, K.T., Trętowicz, M.M., Coskun, E., et al. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. Nature Metabolism, 2025, 7.
- Wongrattanakamon P. Molecular modeling elucidates the cellular mechanism of synaptotagmin-SNARE inhibition: a novel plausible route to anti-wrinkle activity of botox-like cosmetic active molecules. Molecular and Cellular Biochemistry, 2018, 442(1–2), 97–109.
- Wooram Choi, Jeong Hun Cho, Sang Hee Park, et al. Ginseng root-derived exosome-like nanoparticles protect skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the generation of reactive oxygen species. Journal of Ginseng Research, Volume 48, Issue 2, 2024, Pages 211–219.
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Gives a glow
Looking forward to meso and microneedle with left over . Will try to come back and post results in a few months.
Love this new product
Use this for micro needling and my skin is absolutely glowing! Easy to mix up and use and the shipping was lightning fast. This is going to be in my regular rotation from here on out.
I need to try it