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August 21, 2024
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Main Benefits
Advanced hybrid skin-boosting formula developed to support collagen production, tissue regeneration, and overall skin quality. By combining PLLA microparticles, polynucleotides (PN), and hyaluronic acid, it works progressively to improve skin elasticity, hydration, and firmness while supporting long-term dermal regeneration rather than immediate reshaping.
Supports Collagen Production
PLLA microparticles stimulate collagen formation over time, improving skin structure.
Enhances Tissue Regeneration
Polynucleotides activate growth factors that support skin repair and regeneration.
Anti-Inflammatory Support
PN helps reduce inflammatory responses and modulate foreign body reactions.
Improves Skin Elasticity
Gradual collagen regeneration helps improve firmness and elasticity.
Improves Hydration and Texture
Hyaluronic Acid supports moisture retention and smoother skin texture.
Long-Term Skin Quality Improvement
Provides progressive improvement from physical support to tissue regeneration.
Etrebelle PN supports gradual collagen regeneration and skin revitalization, helping improve firmness, texture, and overall skin quality over time.
Indications
Etrebelle PN is indicated for improving overall skin quality and addressing early to moderate signs of skin aging, including:
Loss of skin elasticity and firmness
Fine lines and superficial wrinkles
Dull or tired-looking skin
Dry and dehydrated skin
Uneven skin texture and enlarged pores
Early signs of aging
General facial skin rejuvenation
Mild loss of facial volume associated with skin aging
Ingredients
Polylactic Acid (PLA / PLLA) – 150 mg
Supports collagen stimulation and long-term skin structure improvement.
Polynucleotide (PN) – 35 mg
Supports tissue regeneration and helps modulate inflammatory responses.
Hyaluronic Acid (HA) – 15 mg
Supports skin hydration and improves skin smoothness and comfort.
Etrebelle PN's Microparticle Structure
Etrebelle PN contains PLLA microparticles produced using an emulsification technique, designed to support controlled distribution and gradual collagen stimulation following administration.
Particle Size: PLLA microparticles with a uniform size range of 30–50 µm
Particle Structure: Spherical microparticles formed through emulsification
Surface Characteristics: Smooth microsphere surface without microholes
Distribution Behavior: Designed for even dispersion in the emulsion state
Compatibility: Particle size supports use with 27–32G cannula, helping reduce clogging risk
The uniform size and smooth surface of the PLLA microparticles help support stable placement and gradual tissue response. When combined with polynucleotides (PN), the formulation supports modulation of inflammatory response and progressive collagen regeneration over time.
Mechanism of Action
- Initial Phase – Physical Support
After administration, Etrebelle PN provides physical support within the tissue through its PLLA microparticles. Hyaluronic acid helps distribute the particles evenly, while polynucleotides (PN) help inhibit excessive inflammatory responses associated with foreign body reactions. - Restoration Phase – Collagen Activation
As hyaluronic acid gradually degrades, PLLA microparticles remain evenly positioned within the tissue, contributing to initial volumizing and structural support. During this phase, PN activates essential growth factors and stimulates fibroblast activity, supporting collagen production and tissue regeneration. - Maintenance Phase – Tissue Integration
Over time, PLLA microparticles integrate with the surrounding tissue structure, inducing a collagenesis effect. PN continues to support cell proliferation through growth factor secretion, contributing to improved skin elasticity and dermal quality. - Elimination Phase
As collagen production progresses, the PLLA particles and newly formed collagen become indistinguishable within the tissue. This process enriches the extracellular environment and supports long-term tissue regeneration.
What Makes Etrebelle PN Different?
Etrebelle PN is designed as a hybrid collagen-stimulating and regenerative formulation, combining PLLA microparticles with polynucleotides (PN) and hyaluronic acid to support both structural support and biological regeneration.
Unlike formulations that rely on PLLA alone, Etrebelle PN integrates PN to help modulate inflammatory response and support tissue repair. This synergy allows the product to work progressively, moving from physical support to collagen production and long-term tissue regeneration.
The use of uniform PLLA microparticles supports even distribution and controlled tissue integration, while hyaluronic acid aids particle dispersion during the early phase. Together, these components contribute to gradual improvement in skin elasticity, texture, and overall skin quality rather than immediate volumization.
Product Preparation
Etrebelle PN is supplied as a lyophilized powder and must be reconstituted prior to use.
Reconstitute 1 vial with 6 cc of sterile distilled water
Add 1 cc of lidocaine
Allow the solution to fully rehydrate over approximately 30 minutes
Gently swirl as needed to ensure complete and even suspension of the microparticles
Use the product only once full reconstitution is achieved
Proper reconstitution allows uniform dispersion of the PLLA microparticles and supports consistent handling characteristics during application.
Treatment areas
Face
Etrebelle PN is intended for use in facial skin treatment, supporting overall skin quality, firmness, and rejuvenation of the facial area.
Dosage and technique
Etrebelle PN is applied to the facial area using a controlled, layered approach based on individual skin condition and treatment goals.
Recommended Dosage (per session):
Forehead: up to 3 cc
Temple / lateral facial area: 1 cc
Mid-face / cheek area: 2–3 cc
Nasolabial area: 1–2 cc
Lower face / jawline: 1 cc
Chin / submental area: 3–4 cc
Treatment Technique:
The product is evenly distributed across targeted facial zones to support collagen regeneration and skin strengthening.
Uniform placement allows PLLA microparticles to integrate gradually, while PN supports tissue regeneration and inflammatory modulation.
Cannula compatibility: 27–32G, supporting smooth delivery and controlled distribution.
Post-treatment
After treatment with Etrebelle PN, the treated area should be allowed time to settle as collagen regeneration and tissue response progress gradually.
Mild redness, swelling, or tenderness may occur and typically subsides over time
Gentle massage of the treated area is recommended for 3 days following treatment, as indicated in the source material
Avoid excessive pressure or manipulation of the treated area during the initial recovery period
Normal daily activities may be resumed as tolerated
Results develop progressively as collagen production and tissue regeneration continue over time.
Course of Treatments
How quickly will the result appear?
Before & Afters
What's Inside
Each package contains 1 vial of Etrebelle PN, supplied as a lyophilized formulation for reconstitution prior to use.
- Total content: 436.8 mg per vial
FAQ
Etrebelle PN is designed to support collagen production, tissue regeneration, and overall improvement in skin quality over time.
Etrebelle PN combines PLLA microparticles with polynucleotides (PN) and hyaluronic acid, supporting both structural collagen stimulation and biological tissue regeneration.
Initial support may be noticeable early, while visible improvement continues to develop gradually as collagen production increases over time.
Etrebelle PN works progressively. The main benefits develop gradually as collagen regeneration and tissue integration take place.
Yes. Etrebelle PN is intended for facial treatment.
The effects develop progressively and may be maintained over time as collagen regeneration continues.
How to store
- Store Etrebelle PN in a cool, dry place, away from direct sunlight and heat.
- Keep the vial sealed until use.
- Do not freeze.
- Once reconstituted, use the product promptly according to recommended guidelines.
Please note that our products are intended for use by qualified medical professionals only. We accept no responsibility for any adverse effects or complications resulting from self-administration or misuse. Furthermore, we do not provide compensation for products that have been wasted, damaged, or otherwise improperly used.
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