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Nabota 100U is a high-purity Botulinum Toxin Type A used to smooth facial wrinkles, soften expression lines, and treat muscle-related conditions. Known for its effective and natural-looking results, Nabota is trusted by professionals worldwide for both aesthetic and therapeutic treatments.
Main Benefits of Nabota 100U
Smoother, Younger-Looking Skin
Nabota effectively relaxes the muscles that cause frown lines, forehead wrinkles, and crow’s feet, resulting in visibly smoother and younger-looking skin.
Softens Facial Expressions
By reducing excessive muscle contractions, Nabota helps soften harsh or tense facial expressions, giving a more refreshed and natural appearance without a "frozen" look.
Lifts and Contours Treated Areas
When used strategically, Nabota can gently lift and contour areas such as the eyebrows and jawline, helping improve facial symmetry and definition.
Relieves Muscle Tension
In therapeutic treatments, Nabota helps reduce unwanted muscle spasms and tightness, providing relief in areas like the neck, eyelids, or jaw.
Indications
Nabota 100U is used for both cosmetic and therapeutic purposes. Its primary action is to temporarily reduce muscle activity, leading to smoother skin and relief from muscle-related conditions.
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Facial Rejuvenation & Wrinkle Reduction
Nabota helps reduce the appearance of facial wrinkles, including frown lines, forehead lines, and crow’s feet, resulting in smoother and more youthful-looking skin. -
Facial Contouring & Muscle Relaxation
Relaxes targeted muscles to soften expression lines and improve facial harmony, often used for jaw slimming (masseter reduction) and subtle lifting effects. -
Treatment of Muscle-Related Conditions
Provides relief for conditions such as blepharospasm (involuntary eyelid twitching), cervical dystonia (neck muscle spasm), and spasticity in children with cerebral palsy.
Applicable Treatment Area: Forehead, glabella (between the eyebrows), crow’s feet (around the eyes), masseter muscles (jawline), bunny lines (nose area), and neck. Also used in medical treatments for muscle spasm relief under professional supervision.
How is Nabota made
✅ Manufacturing Process & Technology
Nabota is manufactured using advanced protein purification and biotechnology processes by Daewoong Pharmaceutical Co., Ltd. in South Korea. It is produced through a series of steps involving the controlled fermentation of Clostridium botulinum, followed by extraction, purification, and freeze-drying of the Botulinum Toxin Type A complex into a highly refined powder.
✅ Purity & Filtration
Nabota is known for its high purity, which is one of its key selling points. The toxin undergoes advanced purification to reduce impurities and non-essential proteins. This minimizes the risk of antibody formation in repeat users, helping maintain long-term treatment effectiveness.
This is also why Nabota is considered especially suitable for patients who have previously received botulinum toxin treatments without developing resistance.
✅ Manufacturing Location & Compliance
Nabota is manufactured in South Korea at Daewoong Pharmaceutical’s facilities, which are certified for Good Manufacturing Practices (GMP). It is also approved by the U.S. FDA (under the brand name Jeuveau) and meets international regulatory standards, including Korean MFDS and other health authorities. This confirms its compliance with strict safety, quality, and efficacy requirements.
What Nabota is made of
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Clostridium Botulinum Toxin Type A (100U)
A purified neurotoxin protein that temporarily relaxes targeted muscles to smooth facial wrinkles and reduce muscle-related conditions. -
Human Serum Albumin (0.5 mg)
A stabilizing protein that helps maintain the effectiveness and safety of the botulinum toxin during storage and after reconstitution. -
Sodium Chloride (0.9 mg)
An isotonic agent that ensures the solution is safe and compatible with the body when injected.
Mechanism of action
Nabota works by temporarily blocking the release of acetylcholine, a chemical messenger responsible for muscle contractions. By relaxing targeted muscles, it reduces the appearance of expression lines such as frown lines, forehead wrinkles, and crow’s feet.
When injected into specific facial muscles, Nabota reduces excessive movement, helping the skin to appear smoother and more relaxed. This effect softens existing wrinkles and prevents new ones from forming due to repeated facial expressions.
The active ingredient, Clostridium Botulinum Toxin Type A, inhibits acetylcholine release at the neuromuscular junction, which temporarily reduces muscle activity. As a result, treated areas show visible improvement in fine lines, wrinkles, and muscle-related conditions without affecting untreated areas.
Why does Nabota 100U look Empty? (Video Explanation)
Product preparation
Before use, Nabota must be reconstituted with non-preserved sterile saline (0.9% Sodium Chloride; see dilution table below) using the following steps:
Materials Needed:
Nabota 100U vial (lyophilized powder)
0.9% Sodium Chloride (non-preserved sterile saline)
Appropriate sterile syringe and needle
Alcohol swabs
Gloves
Preparation Steps:
Using an appropriate syringe, draw the required amount of non-preserved sterile saline based on the recommended dilution.
Insert the needle and slowly inject the saline into the Nabota vial, which contains a vacuum.
Inject the saline slowly to avoid forming bubbles.
Gently swirl the vial to mix until the solution is completely clear with no visible particles. Do not shake.
Record the date and time of reconstitution. The solution should be used within 24 hours after preparation.
Store the reconstituted Nabota in a refrigerator at 2–8°C until use.
How to dilute Nabota 100U
Nabota 100U comes as a fine, freeze-dried powder containing 100 units of Botulinum Toxin Type A. It needs to be reconstituted (diluted) with 0.9% Sodium Chloride (saline) before use.
Note: The powder is very fine, so the vial may look empty. Rest assured that all units are present.
|
Diluent Added (0.9% Sodium Chloride) |
||
|---|---|---|
|
NABOTA® 100U |
NABOTA® 200U |
Resulting Dose (U/0.1 mL) |
|
1.0mL |
2.0mL |
10.0U |
|
2.0mL |
4.0mL |
5.0U |
|
2.5mL |
5.0mL |
4.0U |
|
4.0mL |
8.0mL |
2.5U |
|
8.0mL |
16.0mL |
1.25U |
Step-by-Step Dilution Instructions:Take the Nabota 100U vial out of the refrigerator and inspect it. You should see a small amount of white or light-yellow freeze-dried powder.
Using a sterile syringe, draw the desired amount of 0.9% Sodium Chloride based on the dilution you want (see table below).
Slowly inject the saline into the Nabota vial.
Gently swirl the vial (DO NOT shake) until the powder is fully dissolved.
After reconstitution, store the vial in the refrigerator (2–8°C / 35.6–46.4°F) and use it within 24 hours. Studies suggest it may remain stable up to 5 weeks if kept refrigerated properly.
Treatment areas
Nabota 100U can be applied to both aesthetic and therapeutic treatment areas under the supervision of a qualified medical professional.
Face:
Forehead (horizontal forehead lines)
Glabella (frown lines between the eyebrows)
Crow’s feet (wrinkles around the outer corners of the eyes)
Bunny lines (fine lines on the nose)
Masseter muscles (jaw slimming and facial contouring)
Chin (to reduce dimpling)
Perioral area (lines around the mouth)
Eyebrows (for eyebrow lifting)
Body:
Neck (platysmal bands and muscle tension)
Shoulders and upper back (for relief of muscle stiffness)
Lower limbs (in cases of spasticity, especially in children with cerebral palsy)
Areas affected by localized muscle spasms, depending on medical evaluation
Dosage and technique
Nabota 100U is intended for use by licensed medical professionals trained in facial anatomy and injection techniques. Dosage may vary depending on the treatment area, muscle strength, and patient needs.
Recommended Dilution:
100 Units of Nabota + 2.5 mL of 0.9% Sodium Chloride = 4 Units per 0.1 mL
Face:
Glabellar lines (frown lines): 20 units total
(4 units per injection point, 5 injection points: 2 in each corrugator muscle and 1 in the procerus muscle)Forehead lines: 10 to 20 units depending on muscle strength and wrinkle severity
Crow’s feet: 12 units per side (4 units in each of 3 injection points)
Bunny lines (nose): 4 to 6 units divided between both sides
Masseter reduction (jawline slimming): 25 to 50 units per side depending on muscle thickness
Administration Technique:
Use a fine-gauge needle (typically 30–32 gauge).
Inject into the targeted muscle at a 90° angle for superficial muscles, or at a 45° angle for deeper muscles.
Avoid injecting too close to sensitive muscles such as the levator palpebrae superioris to reduce the risk of eyelid drooping.
Gently inject without applying excessive pressure to avoid bruising and diffusion to unintended areas.
Post-treatment
Gently inject without applying excessive pressure to avoid bruising and diffusion to unintended areas.
Avoid rubbing or massaging the treated areas for at least 24 hours after treatment.
Course of Treatments
How quickly will the result appear?
Before & Afters
What's Inside
Each Nabota 100U package contains:
1 vial of Nabota 100U (freeze-dried Botulinum Toxin Type A powder, 100 units)
30G 8mm 0.5cc Insulin Syringe
Saline (for reconstitution)
Pair of latex gloves
Alcohol swabs
FAQ
Nabota 100U is used to reduce facial wrinkles such as frown lines, forehead lines, and crow’s feet. It is also used for medical treatments like muscle spasms (blepharospasm, cervical dystonia) and spasticity in children with cerebral palsy.
Initial results can appear within 3 to 5 days after treatment. The full effect is usually visible within 7 to 14 days.
Results typically last between 3 to 4 months, depending on the treated area and individual response.
Nabota 100U is reconstituted with 2.5 mL of 0.9% sterile saline to achieve a concentration of 4 Units per 0.1 mL. Preparation should only be done by trained medical professionals.
No. Nabota must be administered by a licensed healthcare professional. Self-administration is not recommended and may cause adverse effects.
The vial may look empty due to the extremely fine freeze-dried powder inside. This is normal, and all units are present.
Store Nabota in a refrigerator at 2–8°C (35.6–46.4°F). After reconstitution, use it within 24 hours. Some studies suggest stability for up to 5 weeks when properly refrigerated.
Nabota wholesale access is available for practices that regularly perform botulinum toxin treatments. This Korean-manufactured product is also marketed as Jeuveau in the US market, demonstrating its established safety and efficacy profile. Our wholesale program maintains proper cold-chain protocols and includes complete documentation for professional use. The program requires verification of appropriate licensing and facilities for safe product handling and administration. To learn about Nabota wholesale requirements and begin the application process, please submit our Wholesale Application.
How to properly store
- Store Nabota 100U in a refrigerator at 2–8°C (35.6–46.4°F).
- Do not freeze.
- Protect the vial from direct sunlight and keep it in its original packaging until ready for use.
- After reconstitution, the diluted solution should be stored in a refrigerator and used within 24 hours.
Important Note: Repeated freezing and thawing are not allowed. Doing so may lead to a loss of product activity.
Nabota 100U is intended for professional use only. Administration should be performed by qualified healthcare professionals. We are not liable for misuse, improper storage, or administration outside of recommended guidelines. Furthermore, we do not provide compensation for products that have been wasted, damaged, or otherwise improperly used.
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Product Benefits Helped with armpit sweat
Age 22
I’ve struggled with excessive armpit sweating for years — I tried every deodorant, prescription strength options, and even doctor-recommended treatments, but nothing worked. After using Nabota Tox, everything changed. I applied 50 units in each armpit, and the results have been incredible. I no longer sweat, and for the first time, I feel completely confident wearing any clothes I want without worrying. This has truly been life-changing for me!
Product Benefits Reduced my fine lines and wrinkles
Age 42
I’m 42 years old, and this is my third time purchasing Nabota Tox 100 units. I absolutely love the results — it has made my wrinkles disappear, including the ones on my face and neck. My skin looks smoother, more youthful, and I honestly feel like I look five years younger. This product works beautifully every time and has become one of my must-haves.
I feel so at ease buying from such a wonderful reputable company. I will not buy my skin care anywhere else.
Product Benefits Easy to use and works WONDERFULLY!
I’m a big fan of this product. It starts to kick in pretty quick and lasts several months for me. Ordering is super easy and delivery is VERY fast to the US. Highly recommend.
Website is very user friendly and easy to navigate. There were instructions for every item I looked at. Payment method was super easy using Wise. Meamo walks you through the step-by-step process. The delivery was amazing. I ordered on Thursday 8/28 and my product arrived Wednesday 9/3. I’m in San Diego CA. I haven’t used my product yet but will review once I do. Highly recommend.