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Nabota 200U is a Botulinum Toxin Type A injection used to smooth facial wrinkles, improve muscle-related conditions, and reduce excessive sweating (hyperhidrosis). Nabota is trusted worldwide for its high purity and effectiveness. It provides natural-looking results for frown lines, forehead wrinkles, crow’s feet, and more.
Main Benefits of Nabota 100U
Visibly Smoother and Younger-Looking Skin
Nabota 200U helps reduce wrinkles and fine lines, giving users smoother skin and a more refreshed appearance.
Natural-Looking Facial Expressions
The treatment softens expression lines without creating a stiff or frozen look, allowing for natural and subtle facial movements.
Long-Lasting Results with Fewer Treatments
Results typically last up to 6–8 months, helping users maintain improvements longer and reducing the need for frequent touch-ups.
Comfortable and Safe Treatment Experience
Nabota 200U provides effective results with minimal discomfort and reduced risk of adverse reactions when administered by professionals.
Indications
Nabota 200U is used for both cosmetic and therapeutic purposes. It helps reduce wrinkles, improve muscle-related conditions, and manage excessive sweating.
-
Facial Rejuvenation & Wrinkle Reduction
Nabota 200U smooths wrinkles such as frown lines, forehead lines, crow’s feet, and other facial expression lines for a refreshed and youthful appearance. -
Facial Contouring & Muscle Relaxation
Effectively reduces muscle activity in areas like the masseter muscles, helping slim the jawline and improve facial harmony without affecting natural expressions. -
Treatment of Excessive Sweating (Hyperhidrosis)
Reduces excessive sweating, especially in the palms and soles of the feet, by temporarily blocking the overactive sweat glands. -
Therapeutic Treatment of Muscle-Related Conditions
Used to manage conditions such as blepharospasm (involuntary eyelid twitching) and other localized muscle spasms, improving patient comfort and quality of life.
Applicable Treatment Areas: Forehead horizontal lines, glabella frown lines, crow’s feet around the eyes, bunny lines on the nose, masseter muscles for jaw slimming, perioral lines around the mouth, nasolabial folds or smile lines, neck platysmal bands, palms and soles for hyperhidrosis treatment, eyelids for blepharospasm treatment, and upper and lower limbs for spasticity treatment under medical supervision.
How is Nabota made
✅ Manufacturing Process & Technology
Nabota is manufactured using advanced protein purification and biotechnology processes by Daewoong Pharmaceutical Co., Ltd. in South Korea. It is produced through a series of steps involving the controlled fermentation of Clostridium botulinum, followed by extraction, purification, and freeze-drying of the Botulinum Toxin Type A complex into a highly refined powder.
✅ Purity & Filtration
Nabota is known for its high purity, which is one of its key selling points. The toxin undergoes advanced purification to reduce impurities and non-essential proteins. This minimizes the risk of antibody formation in repeat users, helping maintain long-term treatment effectiveness.
This is also why Nabota is considered especially suitable for patients who have previously received botulinum toxin treatments without developing resistance.
✅ Manufacturing Location & Compliance
Nabota is manufactured in South Korea at Daewoong Pharmaceutical’s facilities, which are certified for Good Manufacturing Practices (GMP). It is also approved by the U.S. FDA (under the brand name Jeuveau) and meets international regulatory standards, including Korean MFDS and other health authorities. This confirms its compliance with strict safety, quality, and efficacy requirements.
What Nabota is made of
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Clostridium Botulinum Toxin Type A (100U)
A purified neurotoxin protein that temporarily relaxes targeted muscles to smooth facial wrinkles and reduce muscle-related conditions. -
Human Serum Albumin (0.5 mg)
A stabilizing protein that helps maintain the effectiveness and safety of the botulinum toxin during storage and after reconstitution. -
Sodium Chloride (0.9 mg)
An isotonic agent that ensures the solution is safe and compatible with the body when injected.
Mechanism of action
Nabota 200U works by temporarily blocking the release of acetylcholine, a neurotransmitter responsible for muscle contractions. When injected into targeted muscles, Nabota relaxes them by preventing nerve signals from triggering excessive movement. This relaxation smooths out wrinkles and expression lines caused by repetitive muscle activity, especially in areas like the forehead, glabella, and around the eyes.
The main ingredient, Clostridium Botulinum Toxin Type A, acts directly at the neuromuscular junction, where nerves communicate with muscles. By stopping acetylcholine release, it temporarily reduces muscle activity without affecting surrounding tissues.
As a result, treated areas show visible improvement with reduced wrinkles and softer facial expressions. In medical cases, the same mechanism helps relieve muscle spasms and hyperactivity.
Why does Nabota 200U look Empty? (Video Explanation)
Product preparation
Before use, Nabota 200U must be reconstituted with non-preserved sterile saline (0.9% Sodium Chloride; see dilution table below) using the following steps:
Materials Needed:
Nabota 200U vial (lyophilized powder)
0.9% Sodium Chloride (non-preserved sterile saline)
Appropriate sterile syringe and needle
Alcohol swabs
Gloves
Preparation Steps:
Using an appropriate syringe, draw the required amount of non-preserved sterile saline based on the recommended dilution.
Insert the needle and slowly inject the saline into the Nabota vial, which contains a vacuum.
Inject the saline slowly to avoid forming bubbles.
Gently swirl the vial to mix until the solution is completely clear with no visible particles. Do not shake.
Record the date and time of reconstitution. The solution should be used within 24 hours after preparation.
Store the reconstituted Nabota in a refrigerator at 2–8°C until use.
How to dilute Nabota 200U
Nabota 100U comes as a fine, freeze-dried powder containing 100 units of Botulinum Toxin Type A. It needs to be reconstituted (diluted) with 0.9% Sodium Chloride (saline) before use.
Note: The powder is very fine, so the vial may look empty. Rest assured that all units are present.
|
Diluent Added (0.9% Sodium Chloride) |
||
|---|---|---|
|
NABOTA® 100U |
NABOTA® 200U |
Resulting Dose (U/0.1 mL) |
|
1.0mL |
2.0mL |
10.0U |
|
2.0mL |
4.0mL |
5.0U |
|
2.5mL |
5.0mL |
4.0U |
|
4.0mL |
8.0mL |
2.5U |
|
8.0mL |
16.0mL |
1.25U |
Step-by-Step Dilution Instructions:Take the Nabota 200U vial out of the refrigerator and inspect it. You should see a small amount of white or light-yellow freeze-dried powder.
Using a sterile syringe, draw the desired amount of 0.9% Sodium Chloride based on the dilution you want (see table below).
Slowly inject the saline into the Nabota vial.
Gently swirl the vial (DO NOT shake) until the powder is fully dissolved.
After reconstitution, store the vial in the refrigerator (2–8°C / 35.6–46.4°F) and use it within 24 hours. Studies suggest it may remain stable up to 5 weeks if kept refrigerated properly.
Treatment areas
Nabota 200U is used for both facial and body treatments under professional supervision. It can be applied to areas where muscle relaxation, wrinkle reduction, or spasm relief is needed.
Face:
Forehead
Glabella (frown lines between the eyebrows)
Crow’s feet (wrinkles around the eyes)
Bunny lines (nose area)
Masseter muscles (jaw slimming)
Perioral lines (around the mouth)
Nasolabial folds (smile lines)
Neck (platysmal bands)
Body:
Palms and soles (for hyperhidrosis treatment)
Eyelids (for blepharospasm treatment)
Upper and lower limbs (for spasticity treatment, especially in children with cerebral palsy)
Dosage and technique
Nabota 100U is intended for use by licensed medical professionals trained in facial anatomy and injection techniques. Dosage may vary depending on the treatment area, muscle strength, and patient needs.
Dosage may vary depending on the treatment area, muscle size, and severity of the condition. Nabota 200U must be administered by trained healthcare professionals familiar with botulinum toxin injections.
Facial Wrinkles:
Glabellar lines (frown lines): 20 units total
(4 units per point across 5 injection points: 2 corrugator muscles and 1 procerus muscle)Forehead lines: 10–20 units
Crow’s feet: 12 units per side (4 units injected into 3 points around each eye)
Bunny lines (nose wrinkles): 4–6 units
Masseter muscles (jaw slimming): 25–50 units per side depending on muscle thickness
Administration Technique:
Inject Nabota 200U intramuscularly using a fine-gauge needle (30–32 gauge recommended).
For superficial muscles (wrinkles), inject at a 90-degree angle.
For deeper muscles (masseter, neck), a 45-degree angle may be used depending on the anatomy.
Avoid injecting near muscles responsible for eyelid or lip elevation to reduce the risk of drooping.
Do not massage or rub the treated area for at least 24 hours after treatment.
Post-treatment
After treatment, avoid rubbing or massaging the treated area unless directed by your doctor. Be careful to prevent bruising or hematoma at the injection site. It is also recommended to avoid excessive heat and strenuous exercise after the procedure.
Course of Treatments
How quickly will the result appear?
Before & Afters
What's Inside
Each Nabota 200U package contains:
Nabota® 200U vial (Purified Botulinum Toxin Type A, lyophilized powder)
30G 8mm 0.5cc Insulin Syringe
Saline (for dilution)
Pair of Latex Gloves
Alcohol Swabs
FAQ
Nabota 200U is used for reducing facial wrinkles, treating muscle spasms such as blepharospasm and cervical dystonia, and managing hyperhidrosis (excessive sweating) in areas like the palms and soles.
Visible improvements usually appear within 3 to 5 days, with full results noticeable within 1 to 2 weeks.
The effects typically last for about 3 to 4 months depending on the treatment area and individual response.
Nabota 200U is reconstituted with 0.9% sterile saline. The recommended dilution and instructions should be followed by a trained healthcare professional.
No. Nabota 200U must be administered by a licensed healthcare professional. Self-injection is not recommended and may lead to adverse effects.
The vial may appear empty because it contains a very fine freeze-dried powder. This is normal, and all active units are present.
Store Nabota 200U in a refrigerator at 2–8°C. After reconstitution, the solution should be used within 24 hours.
Nabota 200U delivers premium wholesale value through its exceptional purity level and rapid onset characteristics within 48-72 hours. This Daewoong Pharmaceuticals product represents the highest quality standards in Korean botulinum toxin manufacturing, making it ideal for practices establishing premium service reputations. The 200-unit concentration provides efficiency for multiple-area treatments and larger muscle groups, optimizing treatment time and patient scheduling. Our wholesale program supports practices investing in premium product quality for discerning clientele. For Nabota 200U wholesale pricing and program eligibility, please submit our Wholesale Application.
How to properly store
- Store Nabota 200U in a refrigerator at 2–8°C.
- Do not freeze.
- Protect the vial from direct sunlight and store it in its original packaging until use.
- After reconstitution, the solution should be stored in a refrigerator and used within 24 hours.
Important Note: Repeated freezing and thawing are not allowed. Doing so may lead to a loss of product activity.
Nabota 200U is intended for professional use only. Administration should be performed by qualified healthcare professionals. We are not liable for misuse, improper storage, or administration outside of recommended guidelines. Furthermore, we do not provide compensation for products that have been wasted, damaged, or otherwise improperly used.
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Fantastic product
Product Benefits Working great and fast
Age 36
I notices the wrinkle goes away after a few days. Works great.
Works great!
Product Benefits Yes
Age 42
Love love love Nabota. Works super fast. Easy to reconstitute. Highly recommend and will continue to buy.
Product Benefits Works fast!
Age 47
First time using this product and within hours I saw slight improvement. I’m currently 6 days since treatment and I ‘m pleasantly surprised by how well this stuff works. Hopefully it lasts long too